Rotundine, 99%

About Rotundine, 99%

Rotundine is a saturated N-heterocycle (Synthesis grade) carrying the CAS registry number 10097-84-4 with a typical assay of 99%. The compound has the formula C21H25NO4, corresponding to a molecular weight of 355.4 g/mol. Its systematic (IUPAC) name is 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline. Alternative names: D,L-Tetrahydropalmatine and Tetrahydropalmatine, (+/-)-.

It is supplied as a solid. Literature values give a melting point of 147 °C and a boiling point of ~482.9 °C. Store in a tightly closed container in a cool, dry and well-ventilated place. It carries the GHS signal word “Danger” with 1 hazard statement. Review the Safety Data Sheet before use.

It is commonly used for organic synthesis and API synthesis. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 100 mg and 1 g packs, Rotundine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Organic synthesis
API synthesis

Industries

Specifications & identifiers

Chemical identifiers
Product name	Rotundine, 99%
Catalogue No.	VQ-012535
CAS Number	10097-84-4
IUPAC name	2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
Molecular formula	C₂₁H₂₅NO₄
Molecular weight	355.4 g/mol
Exact mass	355.1784
Grade	Synthesis
Purity / assay	99%
HSN code	29420090
InChIKey	AEQDJSLRWYMAQI-UHFFFAOYSA-N
SMILES	COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC
PubChem CID	5417

Physical properties
Physical form	Solid
Appearance	Solid
Melting point	147 °C
Boiling point	~482.9 °C
Density	~1.2 g/cm3 (Predicted)
LogP (XLogP3)	3.2
H-bond donors / acceptors	0 / 5
TPSA	40.2 Å²
Synonyms	D,L-Tetrahydropalmatine, Tetrahydropalmatine, (+/-)-, 2,3,9,10-Tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline, Tetrahydropalmatine, dl-, 2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline, 3,4,10,11-tetramethoxy-7,8,12b,13-tetrahydro-5H-6-azatetraphene, Palmatine, Tetrahydro derivative of, 2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline, Rotundine [M+H]+, Tetrahydropalmatine CRS, racemic tetrahydropalmatine

Safety & hazard information (GHS)

Toxic

Signal word: Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements: P264, P270, P301 + P316, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Rotundine, 99%?

The CAS Registry Number of Rotundine, 99% is 10097-84-4. It is also known as D,L-Tetrahydropalmatine, Tetrahydropalmatine, (+/-)-, 2,3,9,10-Tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline.

What is the molecular formula and molecular weight of Rotundine, 99%?

Rotundine, 99% has the molecular formula C21H25NO4 and a molecular weight of 355.4 g/mol. Its IUPAC name is 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline.

Which grade and pack sizes of Rotundine, 99% can I order?

We supply Rotundine, 99% in Synthesis (99%) grade, in 100 mg, 1 g packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Rotundine, 99%?

Yes. Every lot of Rotundine, 99% is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Rotundine, 99% be shipped internationally?

Yes. Rotundine, 99% is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.