Gefapixant

Name: Gefapixant
Brand: Vaqora Chemicals
SKU: VQ-025964

About Gefapixant

Vaqora Chemicals supplies Gefapixant, a high-purity reference standard of Gefapixant registered under CAS number 1015787-98-0. The compound has the formula C14H19N5O4S, corresponding to a molecular weight of 353.4 g/mol. Systematically, it is named 5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide. Common synonyms include AF-219 and Gefapixant(AF-219,MK-7264).

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Gefapixant, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Gefapixant in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Gefapixant

View every impurity, metabolite and intermediate we list for Gefapixant.

Gefapixant impurities

Specifications & identifiers

Chemical identifiers
Product name	Gefapixant
Catalogue No.	VQ-025964
CAS Number	1015787-98-0
IUPAC name	5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide
Molecular formula	C₁₄H₁₉N₅O₄S
Molecular weight	353.4 g/mol
Exact mass	353.1158
Grade	Reference Standard
HSN code	38229090
InChIKey	HLWURFKMDLAKOD-UHFFFAOYSA-N
SMILES	CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)S(=O)(=O)N)OC
PubChem CID	24764487

Physical properties
Physical form	Solid
LogP (XLogP3)	0.7
H-bond donors / acceptors	3 / 9
TPSA	165 Å²
Synonyms	AF-219, 5-[(2,4-diaminopyrimidin-5-yl)oxy]-2-methoxy-4-(propan-2-yl)benzene-1-sulfonamide, Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-, Benzenesulfonamide, 5-((2,4-diamino-5-pyrimidinyl)oxy)-2-methoxy-4-(1-methylethyl)-, 5-((2,4-diaminopyrimidin-5-yl)oxy)-2-methoxy-4-(propan-2-yl)benzene-1-sulfonamide, 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-isopropyl-2-methoxybenzenesulfonamide, Gefapixant(AF-219,MK-7264), 5-[(2,4-Diamino-5-pyrimidinyl)oxy]-4-isopropyl-2-methoxybenzenesulfonamide, 5-[(2,4-diaminopyrimidin-5-yl)oxy]-4-isopropyl-2-methoxybenzenesulfonamide, 5-[2,4-bis(azanyl)pyrimidin-5-yl]oxy-2-methoxy-4-propan-2-yl-benzenesulfonamide, 5-((2,4-Diamino-5-pyrimidinyl)oxy)-4-isopropyl-2-methoxybenzenesulfonamide

Safety & hazard information (GHS)

Health hazard

Signal word: Warning

Hazard statements

H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements: P260, P319, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Gefapixant?

The CAS Registry Number of Gefapixant is 1015787-98-0. It is also known as AF-219, 5-[(2,4-diaminopyrimidin-5-yl)oxy]-2-methoxy-4-(propan-2-yl)benzene-1-sulfonamide, Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-.

What is the molecular formula and molecular weight of Gefapixant?

Gefapixant has the molecular formula C14H19N5O4S and a molecular weight of 353.4 g/mol. Its IUPAC name is 5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide.

What is Gefapixant used for?

Gefapixant is supplied as a characterised reference material related to Gefapixant. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Gefapixant can I order?

We supply Gefapixant in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Gefapixant?

Yes. Every lot of Gefapixant is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Gefapixant be shipped internationally?

Yes. Gefapixant is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.