2-Demethyl Colchicine

Name: 2-Demethyl Colchicine
Brand: Vaqora Chemicals
SKU: VQ-047861

About 2-Demethyl Colchicine

Listed under CAS 102491-80-5, 2-Demethyl Colchicine is a metabolite or degradation product of Colchicine available from Vaqora Chemicals. Formula C21H23NO6, molecular weight 385.4 g/mol. Systematically, it is named N-[(7S)-2-hydroxy-1,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide. Alternative names: O2-Demethylcolchicine and Colchicine, O(2)-demethyl-.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

Analytical teams use this compound to identify metabolites and degradants of Colchicine, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 2-Demethyl Colchicine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Colchicine

View every impurity, metabolite and intermediate we list for Colchicine.

Colchicine impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Demethyl Colchicine
Catalogue No.	VQ-047861
CAS Number	102491-80-5
IUPAC name	N-[(7S)-2-hydroxy-1,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Molecular formula	C₂₁H₂₃NO₆
Molecular weight	385.4 g/mol
Exact mass	385.1525
Grade	Reference Standard
HSN code	38229090
InChIKey	DPOVAJCRYIUTBD-HNNXBMFYSA-N
SMILES	CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)O)OC
PubChem CID	23757

Physical properties
Physical form	Solid
LogP (XLogP3)	0.5
H-bond donors / acceptors	2 / 6
TPSA	94.1 Å²
Synonyms	O2-Demethylcolchicine, Colchicine, O(2)-demethyl-, 2-O-demethyl colchicine, Alkaloid CC 6, from Colchicum cornigerum, O(sup 2)-Demethylcolchicine, COLCHICINE, O(sup 2)-DEMETHYL-, Colchicine, 3-demethyl- (7CI), 2-dimethylcolchicine, N-(2-Hydroxy-1,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Demethyl Colchicine?

The CAS Registry Number of 2-Demethyl Colchicine is 102491-80-5. It is also known as O2-Demethylcolchicine, Colchicine, O(2)-demethyl-, 2-O-demethyl colchicine.

What is the molecular formula and molecular weight of 2-Demethyl Colchicine?

2-Demethyl Colchicine has the molecular formula C21H23NO6 and a molecular weight of 385.4 g/mol. Its IUPAC name is N-[(7S)-2-hydroxy-1,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide.

What is 2-Demethyl Colchicine used for?

2-Demethyl Colchicine is supplied as a characterised reference material related to Colchicine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Demethyl Colchicine can I order?

We supply 2-Demethyl Colchicine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Demethyl Colchicine?

Yes. Every lot of 2-Demethyl Colchicine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Demethyl Colchicine be shipped internationally?

Yes. We export 2-Demethyl Colchicine worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.