R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic… 103733-65-9

Name: R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid
Brand: Vaqora Chemicals
SKU: VQ-032602

About R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid

Vaqora Chemicals supplies R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid, an impurity of Icatibant registered under CAS number 103733-65-9. Formula C10H11NO2, molecular weight 177.2 g/mol. The IUPAC name is (3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid. Common synonyms include D-Tic-OH and D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Icatibant to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Icatibant

View every impurity, metabolite and intermediate we list for Icatibant.

Icatibant impurities

Specifications & identifiers

Chemical identifiers
Product name	R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid
Catalogue No.	VQ-032602
CAS Number	103733-65-9
IUPAC name	(3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Molecular formula	C₁₀H₁₁NO₂
Molecular weight	177.2 g/mol
Exact mass	177.079
Grade	Reference Standard
HSN code	38229090
InChIKey	BWKMGYQJPOAASG-SECBINFHSA-N
SMILES	C1[C@@H](NCC2=CC=CC=C21)C(=O)O
PubChem CID	712398

Physical properties
Physical form	Solid
LogP (XLogP3)	-1.3
H-bond donors / acceptors	2 / 3
TPSA	49.3 Å²
Synonyms	D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, (R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, 3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-, (3R)-, D-Tic-OH, (3R)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, (R)-, D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic, (3R)-1,2,3,4-tetrahydro-3-isoquinolinecarboxlic acid, 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, (+)-, S-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid?

The CAS Registry Number of R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid is 103733-65-9. It is also known as D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, (R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, 3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-, (3R)-.

What is the molecular formula and molecular weight of R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid?

R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid has the molecular formula C10H11NO2 and a molecular weight of 177.2 g/mol. Its IUPAC name is (3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid.

What is R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid used for?

R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid is supplied as a characterised reference material related to Icatibant. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid can I order?

We supply R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid?

Yes. Every lot of R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid be shipped internationally?

Yes. R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.