2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)pheny… 108605-62-5

Name: 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide
Brand: Vaqora Chemicals
SKU: VQ-031460

About 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide

Vaqora Chemicals supplies 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide, a metabolite or degradation product of Leflunomide registered under CAS number 108605-62-5. Its molecular formula is C12H9F3N2O2 and its molecular weight is 270.21 g/mol. Alternative names: (E/Z)-Teriflunomide and Teriflunomide isomer E.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Leflunomide, as well as in QC testing and ANDA/DMF documentation. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Leflunomide

View every impurity, metabolite and intermediate we list for Leflunomide.

Leflunomide impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide
Catalogue No.	VQ-031460
CAS Number	108605-62-5
IUPAC name	2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
Molecular formula	C₁₂H₉F₃N₂O₂
Molecular weight	270.21 g/mol
Exact mass	270.0616
Grade	Reference Standard
HSN code	38229090
InChIKey	UTNUDOFZCWSZMS-UHFFFAOYSA-N
SMILES	CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O
PubChem CID	54677977

Physical properties
Physical form	Solid
LogP (XLogP3)	3.3
H-bond donors / acceptors	2 / 6
TPSA	73.1 Å²
Synonyms	2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide, (E/Z)-Teriflunomide, Teriflunomide isomer E, 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide, 2-cyano-3-hydroxy-n-[4-(trifluoromethyl)phenyl]-2-butenamide, 2-cyano-3-hydroxy-but-2-enoic acid (4-trifluoromethylphenyl)-amide, (2E)-2-[hydroxy-[4-(trifluoromethyl)anilino]methylene]-3-oxo-butanenitrile

Safety & hazard information (GHS)

Toxic

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H360May damage fertility or the unborn child
H412Harmful to aquatic life with long lasting effects

Precautionary statements: P203, P264, P270, P273, P280, P301 + P316, P318, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide?

The CAS Registry Number of 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide is 108605-62-5. It is also known as 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide, (E/Z)-Teriflunomide, Teriflunomide isomer E.

What is the molecular formula and molecular weight of 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide?

2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide has the molecular formula C12H9F3N2O2 and a molecular weight of 270.21 g/mol. Its IUPAC name is 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide.

What is 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide used for?

2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide is supplied as a characterised reference material related to Leflunomide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide can I order?

We supply 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide?

Yes. Every lot of 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide be shipped internationally?

Yes. 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.