Amodiaquine Impurity A (Mannich Base)

About Amodiaquine Impurity A (Mannich Base)

Amodiaquine Impurity A (Mannich Base) is an impurity of Amodiaquine carrying the CAS registry number 121-78-8, specified at 91% purity. Its molecular formula is C13H20N2O2 and its molecular weight is 236.31 g/mol. The IUPAC name is N-[3-(diethylaminomethyl)-4-hydroxyphenyl]acetamide. Alternative names: 4-Acetamido-2-[(diethylamino)methyl]phenol and 3-Diethylamino Acetaminophen.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Amodiaquine to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Amodiaquine

View every impurity, metabolite and intermediate we list for Amodiaquine.

Amodiaquine impurities

Specifications & identifiers

Chemical identifiers
Product name	Amodiaquine Impurity A (Mannich Base)
Catalogue No.	VQ-004382
CAS Number	121-78-8
IUPAC name	N-[3-(diethylaminomethyl)-4-hydroxyphenyl]acetamide
Molecular formula	C₁₃H₂₀N₂O₂
Molecular weight	236.31 g/mol
Exact mass	236.1525
Grade	Reference Standard
Purity / assay	91%
HSN code	38229090
InChIKey	BOUCRWJEKAGKKG-UHFFFAOYSA-N
SMILES	CCN(CC)CC1=C(C=CC(=C1)NC(=O)C)O
PubChem CID	224175

Physical properties
Physical form	Solid
LogP (XLogP3)	1
H-bond donors / acceptors	2 / 3
TPSA	52.6 Å²
Synonyms	N-(3-((Diethylamino)methyl)-4-hydroxyphenyl)acetamide, 4-Acetamido-2-[(diethylamino)methyl]phenol, 3-Diethylamino Acetaminophen, Amodiaquine Diethylamino Acetamide Impurity, 4-Acetamido-2-Diethylaminomethylphenol, n-{3-[(diethylamino)methyl]-4-hydroxyphenyl}acetamide, N-[3-[(Diethylamino)methyl]-4-hydroxyphenyl]acetamide, N-[3-(diethylaminomethyl)-4-hydroxy-phenyl]acetamide, Acetamide, N-[3-[(diethylamino)methyl]-4-hydroxyphenyl]-, 2-Diethylaminomethyl-4-acetylaminophenol, m-Acetotoluidide, .alpha.-(diethylamino)-4'-hydroxy-, Amodiaquine Impurity 17

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P354 + P338, P317, P319, P321, P330, P332 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Amodiaquine Impurity A (Mannich Base)?

The CAS Registry Number of Amodiaquine Impurity A (Mannich Base) is 121-78-8. It is also known as N-(3-((Diethylamino)methyl)-4-hydroxyphenyl)acetamide, 4-Acetamido-2-[(diethylamino)methyl]phenol, 3-Diethylamino Acetaminophen.

What is the molecular formula and molecular weight of Amodiaquine Impurity A (Mannich Base)?

Amodiaquine Impurity A (Mannich Base) has the molecular formula C13H20N2O2 and a molecular weight of 236.31 g/mol. Its IUPAC name is N-[3-(diethylaminomethyl)-4-hydroxyphenyl]acetamide.

What is Amodiaquine Impurity A (Mannich Base) used for?

Amodiaquine Impurity A (Mannich Base) is supplied as a characterised reference material related to Amodiaquine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Amodiaquine Impurity A (Mannich Base) can I order?

We supply Amodiaquine Impurity A (Mannich Base) in Reference Standard (91%) grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg, 500 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Amodiaquine Impurity A (Mannich Base)?

Yes. Every lot of Amodiaquine Impurity A (Mannich Base) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Amodiaquine Impurity A (Mannich Base) be shipped internationally?

Yes. Amodiaquine Impurity A (Mannich Base) is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.