N-Desmethyl Ivabradine HCl

Name: N-Desmethyl Ivabradine HCl
Brand: Vaqora Chemicals
SKU: VQ-022888

About N-Desmethyl Ivabradine HCl

Listed under CAS 1246638-08-3, N-Desmethyl Ivabradine HCl is a metabolite or degradation product of Ivabradine available from Vaqora Chemicals. The compound has the formula C26H35ClN2O5, corresponding to a molecular weight of 491.0 g/mol. Common synonyms include N-Demethyl Ivabradine Hydrochloride and N-desmethyl Ivabradine Hydrochloride.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 1 hazard statement. Review the Safety Data Sheet before use.

Analytical teams use this compound to identify metabolites and degradants of Ivabradine, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Ivabradine

View every impurity, metabolite and intermediate we list for Ivabradine.

Ivabradine impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Desmethyl Ivabradine HCl
Catalogue No.	VQ-022888
CAS Number	1246638-08-3
IUPAC name	3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;hydrochloride
Molecular formula	C₂₆H₃₅ClN₂O₅
Molecular weight	491 g/mol
Exact mass	490.2234
Grade	Reference Standard
HSN code	38229090
InChIKey	MIIIKWNQFDQJGS-VEIFNGETSA-N
SMILES	COC1=C(C=C2CC(=O)N(CCC2=C1)CCCNC[C@H]3CC4=CC(=C(C=C34)OC)OC)OC.Cl
PubChem CID	66672699

Physical properties
Physical form	Solid
H-bond donors / acceptors	2 / 6
TPSA	69.3 Å²
Synonyms	N-Demethyl Ivabradine Hydrochloride, N-desmethyl Ivabradine Hydrochloride, Ivabradine metabolite N-Demethyl Ivabradine (hydrochloride), N-desmethyl Ivabradine (hydrochloride), N-Demethylivabradine Hydrochloride, Ivabradine metabolite N-Demethyl Ivabradine hydrochloride, IvabradinemetaboliteN-DemethylIvabradinehydrochloride

Safety & hazard information (GHS)

Environmental hazard

Signal word: Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P273, P391, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Desmethyl Ivabradine HCl?

The CAS Registry Number of N-Desmethyl Ivabradine HCl is 1246638-08-3. It is also known as N-Demethyl Ivabradine Hydrochloride, N-desmethyl Ivabradine Hydrochloride, Ivabradine metabolite N-Demethyl Ivabradine (hydrochloride).

What is the molecular formula and molecular weight of N-Desmethyl Ivabradine HCl?

N-Desmethyl Ivabradine HCl has the molecular formula C26H35ClN2O5 and a molecular weight of 491 g/mol.

What is N-Desmethyl Ivabradine HCl used for?

N-Desmethyl Ivabradine HCl is supplied as a characterised reference material related to Ivabradine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Desmethyl Ivabradine HCl can I order?

We supply N-Desmethyl Ivabradine HCl in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Desmethyl Ivabradine HCl?

Yes. Every lot of N-Desmethyl Ivabradine HCl is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Desmethyl Ivabradine HCl be shipped internationally?

Yes. N-Desmethyl Ivabradine HCl is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.