O-Desmethyl Adapalene

Name: O-Desmethyl Adapalene
Brand: Vaqora Chemicals
SKU: VQ-021431

About O-Desmethyl Adapalene

O-Desmethyl Adapalene (CAS 125316-60-1) is a metabolite or degradation product of Adapalene offered by Vaqora Chemicals. The compound has the formula C27H26O3, corresponding to a molecular weight of 398.5 g/mol. The IUPAC name is 6-[3-(1-adamantyl)-4-hydroxyphenyl]naphthalene-2-carboxylic acid. Alternative names: Cd 437 and CD-437.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 1 hazard statement. Review the Safety Data Sheet before use.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Adapalene, as well as in QC testing and ANDA/DMF documentation. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies O-Desmethyl Adapalene in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Adapalene

View every impurity, metabolite and intermediate we list for Adapalene.

Adapalene impurities

Specifications & identifiers

Chemical identifiers
Product name	O-Desmethyl Adapalene
Catalogue No.	VQ-021431
CAS Number	125316-60-1
IUPAC name	6-[3-(1-adamantyl)-4-hydroxyphenyl]naphthalene-2-carboxylic acid
Molecular formula	C₂₇H₂₆O₃
Molecular weight	398.5 g/mol
Exact mass	398.1882
Grade	Reference Standard
HSN code	38229090
InChIKey	LDGIHZJOIQSHPB-UHFFFAOYSA-N
SMILES	C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC6=C(C=C5)C=C(C=C6)C(=O)O)O
PubChem CID	135411

Physical properties
Physical form	Solid
LogP (XLogP3)	7.4
H-bond donors / acceptors	2 / 3
TPSA	57.5 Å²
Synonyms	Cd 437, CD-437, 6-(3-(1-adamantyl)-4-hydroxyphenyl)naphthalene-2-carboxylic acid, 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic Acid, 6-(3-(adamantan-1-yl)-4-hydroxyphenyl)-2-naphthoic acid, 2-Naphthalenecarboxylic acid, 6-(4-hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-, 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid, 6-[3-(1-adamantyl)-4-hydroxy-phenyl]naphthalene-2-carboxylic acid, 6-[3-(1-adamantyl)-4-oxidanyl-phenyl]naphthalene-2-carboxylic acid, Apoptosis Activator VI, 2-Naphthalenecarboxylicacid, 6-(4-hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-, 6-(4-Hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphenyl)-2-naphthalenecarboxylic acid

Safety & hazard information (GHS)

Health hazard

Signal word: Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of O-Desmethyl Adapalene?

The CAS Registry Number of O-Desmethyl Adapalene is 125316-60-1. It is also known as Cd 437, CD-437, 6-(3-(1-adamantyl)-4-hydroxyphenyl)naphthalene-2-carboxylic acid.

What is the molecular formula and molecular weight of O-Desmethyl Adapalene?

O-Desmethyl Adapalene has the molecular formula C27H26O3 and a molecular weight of 398.5 g/mol. Its IUPAC name is 6-[3-(1-adamantyl)-4-hydroxyphenyl]naphthalene-2-carboxylic acid.

What is O-Desmethyl Adapalene used for?

O-Desmethyl Adapalene is supplied as a characterised reference material related to Adapalene. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of O-Desmethyl Adapalene can I order?

We supply O-Desmethyl Adapalene in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with O-Desmethyl Adapalene?

Yes. Every lot of O-Desmethyl Adapalene is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can O-Desmethyl Adapalene be shipped internationally?

Yes. O-Desmethyl Adapalene is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.