Netarsudil

Name: Netarsudil
Brand: Vaqora Chemicals
SKU: VQ-007610

About Netarsudil

Vaqora Chemicals supplies Netarsudil, a high-purity reference standard of Netarsudil registered under CAS number 1254032-66-0. Its molecular formula is C28H27N3O3 and its molecular weight is 453.5 g/mol. Its systematic (IUPAC) name is [4-[(2S)-3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate. Alternative names: Rhokiinsa and Rhopressa.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Laboratories use this Netarsudil standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Netarsudil in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Netarsudil

View every impurity, metabolite and intermediate we list for Netarsudil.

Netarsudil impurities

Specifications & identifiers

Chemical identifiers
Product name	Netarsudil
Catalogue No.	VQ-007610
CAS Number	1254032-66-0
Other CAS	1422144-42-0
IUPAC name	[4-[(2S)-3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate
Molecular formula	C₂₈H₂₇N₃O₃
Molecular weight	453.5 g/mol
Exact mass	453.2052
Grade	Reference Standard
HSN code	38229090
InChIKey	OURRXQUGYQRVML-AREMUKBSSA-N
SMILES	CC1=CC(=C(C=C1)C(=O)OCC2=CC=C(C=C2)[C@@H](CN)C(=O)NC3=CC4=C(C=C3)C=NC=C4)C
PubChem CID	66599893

Physical properties
Physical form	Solid
LogP (XLogP3)	4.6
H-bond donors / acceptors	2 / 5
TPSA	94.3 Å²
Synonyms	(S)-4-(3-Amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate, Rhokiinsa, Rhopressa, AR-11324 free base, {4-[(1S)-2-amino-1-[(isoquinolin-6-yl)carbamoyl]ethyl]phenyl}methyl 2,4-dimethylbenzoate, (4-((1S)-2-amino-1-((isoquinolin-6-yl)carbamoyl)ethyl)phenyl)methyl 2,4-dimethylbenzoate, Netarsudil free base, Netarsudil (USAN/INN), ester 60 [PMID: 27072905]

Safety & hazard information (GHS)

Health hazard

Signal word: Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Netarsudil?

The CAS Registry Number of Netarsudil is 1254032-66-0. It is also known as (S)-4-(3-Amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate, Rhokiinsa, Rhopressa.

What is the molecular formula and molecular weight of Netarsudil?

Netarsudil has the molecular formula C28H27N3O3 and a molecular weight of 453.5 g/mol. Its IUPAC name is [4-[(2S)-3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate.

What is Netarsudil used for?

Netarsudil is supplied as a characterised reference material related to Netarsudil. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Netarsudil can I order?

We supply Netarsudil in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Netarsudil?

Yes. Every lot of Netarsudil is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Netarsudil be shipped internationally?

Yes. Netarsudil is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.