Pemetrexed-1-methyl Ester

About Pemetrexed-1-methyl Ester

Pemetrexed-1-methyl Ester is a process intermediate or related compound of Pemetrexed carrying the CAS registry number 1265908-63-1. With the molecular formula C21H23N5O6, it has a molar mass of 441.4 g/mol. Common synonyms include Pemetrexed monomethyl ester.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Good laboratory practice and suitable PPE are recommended during handling.

It is a process intermediate or related compound in the synthesis of Pemetrexed, useful for route development, impurity fate-and-purge studies and analytical method development. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Pemetrexed-1-methyl Ester is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Pemetrexed

View every impurity, metabolite and intermediate we list for Pemetrexed.

Pemetrexed impurities

Specifications & identifiers

Chemical identifiers
Product name	Pemetrexed-1-methyl Ester
Catalogue No.	VQ-013712
CAS Number	1265908-63-1
Other CAS	1265908-61-9
IUPAC name	(4S)-4-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]-5-methoxy-5-oxopentanoic acid
Molecular formula	C₂₁H₂₃N₅O₆
Molecular weight	441.4 g/mol
Exact mass	441.1648
Grade	Reference Standard
HSN code	2933
InChIKey	SMWFKBFNWHXOSN-AWEZNQCLSA-N
SMILES	COC(=O)[C@H](CCC(=O)O)NC(=O)C1=CC=C(C=C1)CCC2=CNC3=C2C(=O)NC(=N3)N
PubChem CID	136598415

Physical properties
Physical form	Solid
LogP (XLogP3)	0.5
H-bond donors / acceptors	5 / 7
TPSA	176 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Pemetrexed-1-methyl Ester?

The CAS Registry Number of Pemetrexed-1-methyl Ester is 1265908-63-1. It is also known as Pemetrexed monomethyl ester.

What is the molecular formula and molecular weight of Pemetrexed-1-methyl Ester?

Pemetrexed-1-methyl Ester has the molecular formula C21H23N5O6 and a molecular weight of 441.4 g/mol. Its IUPAC name is (4S)-4-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]-5-methoxy-5-oxopentanoic acid.

What is Pemetrexed-1-methyl Ester used for?

Pemetrexed-1-methyl Ester is supplied as a characterised reference material related to Pemetrexed. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Pemetrexed-1-methyl Ester can I order?

We supply Pemetrexed-1-methyl Ester in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Pemetrexed-1-methyl Ester?

Yes. Every lot of Pemetrexed-1-methyl Ester is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Pemetrexed-1-methyl Ester be shipped internationally?

Yes. We export Pemetrexed-1-methyl Ester worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.