(2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane

About (2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane

(2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane is an impurity of Nebivolol carrying the CAS registry number 129050-23-3. The compound has the formula C11H11FO2, corresponding to a molecular weight of 194.2 g/mol. Systematically, it is named (2S)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-chromene. Common synonyms include (S)-6-fluoro-2-((S)-oxiran-2-yl)chroman and (S)-6-Fluoro-2-((S)-oxiran-2-yl)chromane.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Nebivolol to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer (2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Nebivolol

View every impurity, metabolite and intermediate we list for Nebivolol.

Nebivolol impurities

Specifications & identifiers

Chemical identifiers
Product name	(2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane
Catalogue No.	VQ-026849
CAS Number	129050-23-3
IUPAC name	(2S)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-chromene
Molecular formula	C₁₁H₁₁FO₂
Molecular weight	194.2 g/mol
Exact mass	194.0743
Grade	Reference Standard
HSN code	38229090
InChIKey	GVZDIJGBXSDSEP-QWRGUYRKSA-N
SMILES	C1CC2=C(C=CC(=C2)F)O[C@@H]1[C@@H]3CO3
PubChem CID	20575861

Physical properties
Physical form	Solid
LogP (XLogP3)	2.1
H-bond donors / acceptors	0 / 3
TPSA	21.8 Å²
Synonyms	rel-(2R)-6-Fluoro-3,4-dihydro-2-(2R)-2-oxiranyl-2H-1-benzopyran, (+)-(S,S)-6-Fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran, (2S)-6-Fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene, (S)-6-fluoro-2-((S)-oxiran-2-yl)chroman, (2S)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran, (S)-6-Fluoro-2-((S)-oxiran-2-yl)chromane, (2S)-6-fluoro-2-[(2S)-oxiran-2-yl]chromane, 2H-a1-aBenzopyran, 6-afluoro-a3,a4-adihydro-a2-a[(2S)a-a2-aoxiranyl]a-a, (2S)a-

Safety & hazard information (GHS)

Harmful / irritant

Environmental hazard

Signal word: Warning

Hazard statements

H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P261, P264, P264 + P265, P271, P272, P273, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P333 + P317, P337 + P317, P362 + P364, P391, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane?

The CAS Registry Number of (2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane is 129050-23-3. It is also known as rel-(2R)-6-Fluoro-3,4-dihydro-2-(2R)-2-oxiranyl-2H-1-benzopyran, (+)-(S,S)-6-Fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran, (2S)-6-Fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene.

What is the molecular formula and molecular weight of (2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane?

(2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane has the molecular formula C11H11FO2 and a molecular weight of 194.2 g/mol. Its IUPAC name is (2S)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-chromene.

What is (2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane used for?

(2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane is supplied as a characterised reference material related to Nebivolol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane can I order?

We supply (2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane?

Yes. Every lot of (2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane be shipped internationally?

Yes. (2S, 2'S)-6-Fluoro-2-(2′-oxiranyl)chromane is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.