Diphenhydramine N-Oxide Hydrochloride

Name: Diphenhydramine N-Oxide Hydrochloride
Brand: Vaqora Chemicals
SKU: VQ-025339

About Diphenhydramine N-Oxide Hydrochloride

Listed under CAS 13168-00-8, Diphenhydramine N-Oxide Hydrochloride is a metabolite or degradation product of Diphenhydramine available from Vaqora Chemicals. Its molecular formula is C17H22ClNO2 and its molecular weight is 307.8 g/mol. It is also known as Diphenhydramine N-Oxide (HCl Salt) or Benadryl N-oxide hydrochloride.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Analytical teams use this compound to identify metabolites and degradants of Diphenhydramine, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Diphenhydramine N-Oxide Hydrochloride in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Diphenhydramine

View every impurity, metabolite and intermediate we list for Diphenhydramine.

Diphenhydramine impurities

Specifications & identifiers

Chemical identifiers
Product name	Diphenhydramine N-Oxide Hydrochloride
Catalogue No.	VQ-025339
CAS Number	13168-00-8
IUPAC name	2-benzhydryloxy-N,N-dimethylethanamine oxide;hydrochloride
Molecular formula	C₁₇H₂₂ClNO₂
Molecular weight	307.8 g/mol
Exact mass	307.1339
Grade	Reference Standard
HSN code	38229090
InChIKey	JWWPHMSWVFMLIF-UHFFFAOYSA-N
SMILES	C[N+](C)(CCOC(C1=CC=CC=C1)C2=CC=CC=C2)[O-].Cl
PubChem CID	131872116

Physical properties
Physical form	Solid
H-bond donors / acceptors	1 / 2
TPSA	27.3 Å²
Synonyms	Diphenhydramine N-Oxide (HCl Salt), Benadryl N-oxide hydrochloride, Benadryl N-oxide HCl, Benzdryl hydrochloride N-oxide, N-Oxide of benadryl hydrochloride, N,N-Dimethyl-2-(diphenylmethoxy)ethylamine N-oxide hydrochloride, DiphenhydramineN-oxide, 2-(Benzhydryloxy)-N,N-dimethylethan-1-amine oxide hydrochloride, 2-(BenZhydryloxy)-N,N-dimethylethanamine oxide hydrochloride

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Diphenhydramine N-Oxide Hydrochloride?

The CAS Registry Number of Diphenhydramine N-Oxide Hydrochloride is 13168-00-8. It is also known as Diphenhydramine N-Oxide (HCl Salt), Benadryl N-oxide hydrochloride, Benadryl N-oxide HCl.

What is the molecular formula and molecular weight of Diphenhydramine N-Oxide Hydrochloride?

Diphenhydramine N-Oxide Hydrochloride has the molecular formula C17H22ClNO2 and a molecular weight of 307.8 g/mol.

What is Diphenhydramine N-Oxide Hydrochloride used for?

Diphenhydramine N-Oxide Hydrochloride is supplied as a characterised reference material related to Diphenhydramine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Diphenhydramine N-Oxide Hydrochloride can I order?

We supply Diphenhydramine N-Oxide Hydrochloride in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Diphenhydramine N-Oxide Hydrochloride?

Yes. Every lot of Diphenhydramine N-Oxide Hydrochloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Diphenhydramine N-Oxide Hydrochloride be shipped internationally?

Yes. Diphenhydramine N-Oxide Hydrochloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.