N-Nitroso Metoprolol

About N-Nitroso Metoprolol

N-Nitroso Metoprolol is a nitrosamine impurity of Metoprolol carrying the CAS registry number 138768-62-4 with a typical assay of 97%. Its molecular formula is C15H24N2O4 and its molecular weight is 296.36 g/mol. The IUPAC name is N-[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl]-N-propan-2-ylnitrous amide. Alternative names: N-Nitrosometoprolol and N-nitroso-metoprolol.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Metoprolol, method validation (AMV) and regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer N-Nitroso Metoprolol in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. Stock is available for quick dispatch.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Metoprolol

View every impurity, metabolite and intermediate we list for Metoprolol.

Metoprolol impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Nitroso Metoprolol
Catalogue No.	VQ-006918
CAS Number	138768-62-4
IUPAC name	N-[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl]-N-propan-2-ylnitrous amide
Molecular formula	C₁₅H₂₄N₂O₄
Molecular weight	296.36 g/mol
Exact mass	296.1736
Grade	Reference Standard
Purity / assay	97%
HSN code	38229090
InChIKey	CHTOBGHTYDROBB-UHFFFAOYSA-N
SMILES	CC(C)N(CC(COC1=CC=C(C=C1)CCOC)O)N=O
PubChem CID	154449

Physical properties
Physical form	Solid
LogP (XLogP3)	2.2
H-bond donors / acceptors	1 / 6
TPSA	71.4 Å²
Synonyms	N-(2-Hydroxy-3-(4-(2-methoxyethyl)phenoxy)propyl)-N-isopropylnitrous amide, 1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)nitrosoamino]-2-propanol, N-Nitrosometoprolol, 1-[4-(2-methoxyethyl)phenoxy]-3-[nitroso(propan-2-yl)amino]propan-2-ol, 1-(4-(2-methoxyethyl)phenoxy)-3-(nitroso(propan-2-yl)amino)propan-2-ol, N-nitroso-metoprolol, N-{2-Hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl}-N-propan-2-ylnitrous amide, (+-)-1-(4-(2-Methoxyethyl)phenoxy)-3-((1-methylethyl)nitrosoamino)-2-propanol, 2-Propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)nitrosoamino)-, (+-)-, 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)nitrosoamino]-, N-[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl]-N-isopropyl-nitrous amide, N-{2-Hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl}-N-(propan-2-yl)nitrous amide

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H351Suspected of causing cancer

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Nitroso Metoprolol?

The CAS Registry Number of N-Nitroso Metoprolol is 138768-62-4. It is also known as N-(2-Hydroxy-3-(4-(2-methoxyethyl)phenoxy)propyl)-N-isopropylnitrous amide, 1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)nitrosoamino]-2-propanol, N-Nitrosometoprolol.

What is the molecular formula and molecular weight of N-Nitroso Metoprolol?

N-Nitroso Metoprolol has the molecular formula C15H24N2O4 and a molecular weight of 296.36 g/mol. Its IUPAC name is N-[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl]-N-propan-2-ylnitrous amide.

What is N-Nitroso Metoprolol used for?

N-Nitroso Metoprolol is supplied as a characterised reference material related to Metoprolol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Nitroso Metoprolol can I order?

We supply N-Nitroso Metoprolol in Reference Standard (97%) grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Nitroso Metoprolol?

Yes. Every lot of N-Nitroso Metoprolol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Nitroso Metoprolol be shipped internationally?

Yes. N-Nitroso Metoprolol is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.