Benzathine

About Benzathine

Benzathine is an impurity of Penicillin carrying the CAS registry number 140-28-3. Its molecular formula is C16H20N2 and its molecular weight is 240.34 g/mol. The IUPAC name is N,N'-dibenzylethane-1,2-diamine. Common synonyms include N,N'-Dibenzylethylenediamine and Benzatin.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

This Penicillin impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Benzathine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Penicillin

View every impurity, metabolite and intermediate we list for Penicillin.

Penicillin impurities

Specifications & identifiers

Chemical identifiers
Product name	Benzathine
Catalogue No.	VQ-043997
CAS Number	140-28-3
IUPAC name	N,N'-dibenzylethane-1,2-diamine
Molecular formula	C₁₆H₂₀N₂
Molecular weight	240.34 g/mol
Exact mass	240.1626
Grade	Reference Standard
HSN code	38229090
InChIKey	JUHORIMYRDESRB-UHFFFAOYSA-N
SMILES	C1=CC=C(C=C1)CNCCNCC2=CC=CC=C2
PubChem CID	8793

Physical properties
Physical form	Solid
LogP (XLogP3)	2.4
H-bond donors / acceptors	2 / 2
TPSA	24.1 Å²
Synonyms	N,N'-Dibenzylethylenediamine, Benzatin, 1,2-Bis(benzylamino)ethane, N,N'-Dibenzyl-1,2-ethylenediamine, N1,N2-Dibenzylethane-1,2-diamine, N,N'-Dibenzyl-ethane-1,2-diamine, 1,2-Ethanediamine, N,N'-bis(phenylmethyl)-, benzyl[2-(benzylamino)ethyl]amine, 1,2-Ethanediamine, N1,N2-bis(phenylmethyl)-, N,N'-dibenzylethylene-diamine, Ethylenediamine,N'-dibenzyl-, 1, N,N'-bis(phenylmethyl)-

Safety & hazard information (GHS)

Corrosive

Toxic

Harmful / irritant

Environmental hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P260, P261, P264, P264 + P265, P270, P271, P273, P280, P301 + P316, P301 + P317, P301 + P330 + P331, P302 + P352, P302 + P361 + P354, P304 + P340, P305 + P351 + P338, P305 + P354 + P338, P316, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Benzathine?

The CAS Registry Number of Benzathine is 140-28-3. It is also known as N,N'-Dibenzylethylenediamine, Benzatin, 1,2-Bis(benzylamino)ethane.

What is the molecular formula and molecular weight of Benzathine?

Benzathine has the molecular formula C16H20N2 and a molecular weight of 240.34 g/mol. Its IUPAC name is N,N'-dibenzylethane-1,2-diamine.

What is Benzathine used for?

Benzathine is supplied as a characterised reference material related to Penicillin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Benzathine can I order?

We supply Benzathine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Benzathine?

Yes. Every lot of Benzathine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Benzathine be shipped internationally?

Yes. Benzathine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.