Enasidenib

About Enasidenib

Enasidenib is a high-purity reference standard of Enasidenib carrying the CAS registry number 1446502-11-9. The compound has the formula C19H17F6N7O, corresponding to a molecular weight of 473.4 g/mol. Common synonyms include AG-221 and AG-221 (Enasidenib).

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As a reference sample of Enasidenib, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Enasidenib

View every impurity, metabolite and intermediate we list for Enasidenib.

Enasidenib impurities

Specifications & identifiers

Chemical identifiers
Product name	Enasidenib
Catalogue No.	VQ-036987
CAS Number	1446502-11-9
IUPAC name	2-methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol
Molecular formula	C₁₉H₁₇F₆N₇O
Molecular weight	473.4 g/mol
Exact mass	473.1399
Grade	Reference Standard
HSN code	38229090
InChIKey	DYLUUSLLRIQKOE-UHFFFAOYSA-N
SMILES	CC(C)(CNC1=NC(=NC(=N1)C2=NC(=CC=C2)C(F)(F)F)NC3=CC(=NC=C3)C(F)(F)F)O
PubChem CID	89683805

Physical properties
Physical form	Solid
LogP (XLogP3)	3.5
H-bond donors / acceptors	3 / 14
TPSA	109 Å²
Synonyms	AG-221, AG-221 (Enasidenib), AG 221, EX-A654, AG-221(Enasidenib)

Safety & hazard information (GHS)

Health hazard

Signal word: Danger

Hazard statements

H360May damage fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure
H413May cause long lasting harmful effects to aquatic life

Precautionary statements: P203, P260, P273, P280, P318, P319, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Enasidenib?

The CAS Registry Number of Enasidenib is 1446502-11-9. It is also known as AG-221, AG-221 (Enasidenib), AG 221.

What is the molecular formula and molecular weight of Enasidenib?

Enasidenib has the molecular formula C19H17F6N7O and a molecular weight of 473.4 g/mol. Its IUPAC name is 2-methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol.

What is Enasidenib used for?

Enasidenib is supplied as a characterised reference material related to Enasidenib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Enasidenib can I order?

We supply Enasidenib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Enasidenib?

Yes. Every lot of Enasidenib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Enasidenib be shipped internationally?

Yes. Enasidenib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.