(S)-Lorlatinib

About (S)-Lorlatinib

(S)-Lorlatinib is a high-purity reference standard of Lorlatinib carrying the CAS registry number 1454847-76-7. Formula C21H19FN6O2, molecular weight 406.4 g/mol. Common synonyms include Lorlatinib S Isomer and Lorlatinib (S) Isomer.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Good laboratory practice and suitable PPE are recommended during handling.

Laboratories use this Lorlatinib standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, (S)-Lorlatinib is dispatched with a Certificate of Analysis (COA) to destinations worldwide. A Safety Data Sheet (SDS) and technical specifications are available on request.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Lorlatinib

View every impurity, metabolite and intermediate we list for Lorlatinib.

Lorlatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	(S)-Lorlatinib
Catalogue No.	VQ-031639
CAS Number	1454847-76-7
IUPAC name	(16S)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetrazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaene-3-carbonitrile
Molecular formula	C₂₁H₁₉FN₆O₂
Molecular weight	406.4 g/mol
Exact mass	406.1554
Grade	Reference Standard
HSN code	38229090
InChIKey	IIXWYSCJSQVBQM-NSHDSACASA-N
SMILES	C[C@H]1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C
PubChem CID	89808119

Physical properties
Physical form	Solid
LogP (XLogP3)	1.5
H-bond donors / acceptors	1 / 7
TPSA	110 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (S)-Lorlatinib?

The CAS Registry Number of (S)-Lorlatinib is 1454847-76-7. It is also known as Lorlatinib S Isomer, Lorlatinib (S) Isomer, US10543199, Compound 28.

What is the molecular formula and molecular weight of (S)-Lorlatinib?

(S)-Lorlatinib has the molecular formula C21H19FN6O2 and a molecular weight of 406.4 g/mol. Its IUPAC name is (16S)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetrazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaene-3-carbonitrile.

What is (S)-Lorlatinib used for?

(S)-Lorlatinib is supplied as a characterised reference material related to Lorlatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (S)-Lorlatinib can I order?

We supply (S)-Lorlatinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (S)-Lorlatinib?

Yes. Every lot of (S)-Lorlatinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (S)-Lorlatinib be shipped internationally?

Yes. We export (S)-Lorlatinib worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.