2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine 149082-03-1

About 2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine

2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine is an impurity of Esomeprazole carrying the CAS registry number 149082-03-1. The compound has the formula C8H10N2O3, corresponding to a molecular weight of 182.18 g/mol. Its systematic (IUPAC) name is (3,5-dimethyl-4-nitro-2-pyridinyl)methanol. Common synonyms include (3,5-Dimethyl-4-nitropyridin-2-yl)methanol and 3,5-Dimethyl-4-nitro-2-pyridinemethanol.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Esomeprazole to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Esomeprazole

View every impurity, metabolite and intermediate we list for Esomeprazole.

Esomeprazole impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine
Catalogue No.	VQ-044142
CAS Number	149082-03-1
IUPAC name	(3,5-dimethyl-4-nitro-2-pyridinyl)methanol
Molecular formula	C₈H₁₀N₂O₃
Molecular weight	182.18 g/mol
Exact mass	182.0691
Grade	Reference Standard
HSN code	38229090
InChIKey	KBCDOXSSYLFMHH-UHFFFAOYSA-N
SMILES	CC1=CN=C(C(=C1[N+](=O)[O-])C)CO
PubChem CID	4049415

Physical properties
Physical form	Solid
LogP (XLogP3)	0.6
H-bond donors / acceptors	1 / 4
TPSA	78.9 Å²
Synonyms	(3,5-Dimethyl-4-nitropyridin-2-yl)methanol, 3,5-Dimethyl-4-nitro-2-pyridinemethanol, 3,5-Dimethyl-2-hydroxymethyl-4-nitropyridine, 2-Pyridinemethanol, 3,5-dimethyl-4-nitro-, 3,5-Dimethyl-4-nitropyridine-2-methanol, (3,5-dimethyl-4-nitro-2-pyridyl)methan-1-ol, 4-Nitro-3,5-dimethyl-2-(hydroxymethyl)pyridine

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine?

The CAS Registry Number of 2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine is 149082-03-1. It is also known as (3,5-Dimethyl-4-nitropyridin-2-yl)methanol, 3,5-Dimethyl-4-nitro-2-pyridinemethanol, 3,5-Dimethyl-2-hydroxymethyl-4-nitropyridine.

What is the molecular formula and molecular weight of 2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine?

2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine has the molecular formula C8H10N2O3 and a molecular weight of 182.18 g/mol. Its IUPAC name is (3,5-dimethyl-4-nitro-2-pyridinyl)methanol.

What is 2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine used for?

2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine is supplied as a characterised reference material related to Esomeprazole. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine can I order?

We supply 2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine?

Yes. Every lot of 2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine be shipped internationally?

Yes. 2-Hydroxymethyl-3,5-dimethyl-4-nitropyridine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.