Metformin Impurity E (Freebase)

About Metformin Impurity E (Freebase)

Metformin Impurity E (Freebase) is an impurity of Metformin carrying the CAS registry number 1609-00-3. Its molecular formula is C3H9N5 and its molecular weight is 115.14 g/mol. Its systematic (IUPAC) name is 1-(diaminomethylidene)-2-methylguanidine. Alternative names: 1-Methylbiguanide and N-Methyl-N'-guanylguanidine.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

Pharmaceutical QC and development laboratories use this impurity standard of Metformin to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Metformin

View every impurity, metabolite and intermediate we list for Metformin.

Metformin impurities

Specifications & identifiers

Chemical identifiers
Product name	Metformin Impurity E (Freebase)
Catalogue No.	VQ-005264
CAS Number	1609-00-3
IUPAC name	1-(diaminomethylidene)-2-methylguanidine
Molecular formula	C₃H₉N₅
Molecular weight	115.14 g/mol
Exact mass	115.0858
Grade	Reference Standard
HSN code	38229090
InChIKey	JLPWQEHTPOFCPG-UHFFFAOYSA-N
SMILES	CN=C(N)N=C(N)N
PubChem CID	15486

Physical properties
Physical form	Solid
LogP (XLogP3)	-1.8
H-bond donors / acceptors	3 / 1
TPSA	103 Å²
Synonyms	1-Methylbiguanide, N-Methyl-N'-guanylguanidine, N-Methyl-imidodicarbonimidic Diamide, Metformin hydrochloride impurity E, N-methylimidodicarbonimidic diamide, Metformin EP impurity E, C3H9N5, 1-(diaminomethylene)-2-methyl-guanidine, N-(Diaminomethylidene)-N''-methylguanidine, 1-Methyl-Biguanide (Metformin Impurity pound(c), 1-[(diaminomethylidene)amino]-N-methylmethanimidamide, N-Desmethyl Metformin Hemisulfate Monohydrate

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Metformin Impurity E (Freebase)?

The CAS Registry Number of Metformin Impurity E (Freebase) is 1609-00-3. It is also known as 1-Methylbiguanide, N-Methyl-N'-guanylguanidine, N-Methyl-imidodicarbonimidic Diamide.

What is the molecular formula and molecular weight of Metformin Impurity E (Freebase)?

Metformin Impurity E (Freebase) has the molecular formula C3H9N5 and a molecular weight of 115.14 g/mol. Its IUPAC name is 1-(diaminomethylidene)-2-methylguanidine.

What is Metformin Impurity E (Freebase) used for?

Metformin Impurity E (Freebase) is supplied as a characterised reference material related to Metformin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Metformin Impurity E (Freebase) can I order?

We supply Metformin Impurity E (Freebase) in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Metformin Impurity E (Freebase)?

Yes. Every lot of Metformin Impurity E (Freebase) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Metformin Impurity E (Freebase) be shipped internationally?

Yes. We export Metformin Impurity E (Freebase) worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.