Desmethyl Erlotinib

Name: Desmethyl Erlotinib
Brand: Vaqora Chemicals
SKU: VQ-007143

About Desmethyl Erlotinib

Listed under CAS 183321-86-0, Desmethyl Erlotinib is a metabolite or degradation product of Erlotinib available from Vaqora Chemicals. Its molecular formula is C21H21N3O4 and its molecular weight is 379.4 g/mol. Systematically, it is named 2-[4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethanol. Alternative names: Erlotinib O-Desmethyl Metabolite (M14) and OSI-420, Free Base (Desmethyl Erlotinib).

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

Analytical teams use this compound to identify metabolites and degradants of Erlotinib, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Desmethyl Erlotinib is dispatched with a Certificate of Analysis (COA) to destinations worldwide. Stock is available for quick dispatch.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Erlotinib

View every impurity, metabolite and intermediate we list for Erlotinib.

Erlotinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Desmethyl Erlotinib
Catalogue No.	VQ-007143
CAS Number	183321-86-0
Other CAS	183320-51-6
IUPAC name	2-[4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethanol
Molecular formula	C₂₁H₂₁N₃O₄
Molecular weight	379.4 g/mol
Exact mass	379.1532
Grade	Reference Standard
HSN code	38229090
InChIKey	KOQIAZNBAWFSQM-UHFFFAOYSA-N
SMILES	COCCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCO
PubChem CID	10317566

Physical properties
Physical form	Solid
LogP (XLogP3)	2.8
H-bond donors / acceptors	2 / 7
TPSA	85.7 Å²
Synonyms	2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol, Erlotinib O-Desmethyl Metabolite (M14), OSI-420, Free Base (Desmethyl Erlotinib), OSI-420, Erlotinib metabolite M14, 2-[[4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]ethanol, Ethanol, 2-[[4-[(3-ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]-, 2-(4-(3-Ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxyethanol, Ethanol, 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)-6-quinazolinyl)oxy)-, OSI 420, 6-O-Desmethyl-erlotinib, EX-A064-1

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Desmethyl Erlotinib?

The CAS Registry Number of Desmethyl Erlotinib is 183321-86-0. It is also known as 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol, Erlotinib O-Desmethyl Metabolite (M14), OSI-420, Free Base (Desmethyl Erlotinib).

What is the molecular formula and molecular weight of Desmethyl Erlotinib?

Desmethyl Erlotinib has the molecular formula C21H21N3O4 and a molecular weight of 379.4 g/mol. Its IUPAC name is 2-[4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethanol.

What is Desmethyl Erlotinib used for?

Desmethyl Erlotinib is supplied as a characterised reference material related to Erlotinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Desmethyl Erlotinib can I order?

We supply Desmethyl Erlotinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Desmethyl Erlotinib?

Yes. Every lot of Desmethyl Erlotinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Desmethyl Erlotinib be shipped internationally?

Yes. We export Desmethyl Erlotinib worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.