Ambroxol Impurity B

About Ambroxol Impurity B

Ambroxol Impurity B is an impurity of Ambroxol carrying the CAS registry number 18683-95-9. With the molecular formula C14H18Br2N2O, it has a molar mass of 390.11 g/mol. The IUPAC name is 4-(6,8-dibromo-2,4-dihydro-1H-quinazolin-3-yl)cyclohexan-1-ol. Alternative names: NA 873 and Ambroxol EP Impurity B.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

Pharmaceutical QC and development laboratories use this impurity standard of Ambroxol to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer Ambroxol Impurity B in 10 mg and 25 mg packs with a batch-specific COA, and ship to customers worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Ambroxol

View every impurity, metabolite and intermediate we list for Ambroxol.

Ambroxol impurities

Specifications & identifiers

Chemical identifiers
Product name	Ambroxol Impurity B
Catalogue No.	VQ-004363
CAS Number	18683-95-9
Other CAS	15942-08-2
IUPAC name	4-(6,8-dibromo-2,4-dihydro-1H-quinazolin-3-yl)cyclohexan-1-ol
Molecular formula	C₁₄H₁₈Br₂N₂O
Molecular weight	390.11 g/mol
Exact mass	389.9765
Grade	Reference Standard
HSN code	38229090
InChIKey	AJOQVCHLLULVGK-UHFFFAOYSA-N
SMILES	C1CC(CCC1N2CC3=C(C(=CC(=C3)Br)Br)NC2)O
PubChem CID	52914942

Physical properties
Physical form	Solid
LogP (XLogP3)	3.6
H-bond donors / acceptors	2 / 3
TPSA	35.5 Å²
Synonyms	(1R,4R)-4-(6,8-dibromo-1,2-dihydroquinazolin-3(4H)-yl)cyclohexanol, trans-4-(6,8-Dibromo-1,4-dihydro-3(2H)-quinazolinyl)cyclohexanol, NA 873, Ambroxol EP Impurity B, trans-4-(6,8-Dibromo-1,2-dihydroquinazolin-3(4H)-yl)cyclohexanol, 4-(6,8-dibromo-1,4-dihydroquinazolin-3(2H)-yl)cyclohexan-1-ol, Ambroxol Impurity 45, Ambroxol Hydrochloride EP Impurity B, (1r,4r)-4-(6,8-dibromo-1,4-dihydroquinazolin-3(2H)-yl)cyclohexan-1-ol, rel-(1s,4s)-4-(6,8-Dibromo-1,2-dihydroquinazolin-3(4H)-yl)cyclohexanol, 6,8-Dibromo-3-(4?-hydroxycyclohexane-1?-yl)-1,2,3,4-tetrahydroquinazoline

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Ambroxol Impurity B?

The CAS Registry Number of Ambroxol Impurity B is 18683-95-9. It is also known as (1R,4R)-4-(6,8-dibromo-1,2-dihydroquinazolin-3(4H)-yl)cyclohexanol, trans-4-(6,8-Dibromo-1,4-dihydro-3(2H)-quinazolinyl)cyclohexanol, NA 873.

What is the molecular formula and molecular weight of Ambroxol Impurity B?

Ambroxol Impurity B has the molecular formula C14H18Br2N2O and a molecular weight of 390.11 g/mol. Its IUPAC name is 4-(6,8-dibromo-2,4-dihydro-1H-quinazolin-3-yl)cyclohexan-1-ol.

What is Ambroxol Impurity B used for?

Ambroxol Impurity B is supplied as a characterised reference material related to Ambroxol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Ambroxol Impurity B can I order?

We supply Ambroxol Impurity B in Reference Standard grade, in 10 mg, 25 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Ambroxol Impurity B?

Yes. Every lot of Ambroxol Impurity B is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Ambroxol Impurity B be shipped internationally?

Yes. We export Ambroxol Impurity B worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.