Cyclo-(Pro-Gly)

About Cyclo-(Pro-Gly)

Cyclo-(Pro-Gly) is an impurity of Vildagliptin carrying the CAS registry number 19179-12-5. With the molecular formula C7H10N2O2, it has a molar mass of 154.17 g/mol. Its systematic (IUPAC) name is 2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione. It is also known as Cyclo(glycylprolyl) or Cyclo(gly-pro).

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Warning” with 3 hazard statements. Review the Safety Data Sheet before use.

As a characterised impurity of Vildagliptin, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Cyclo-(Pro-Gly) in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Vildagliptin

View every impurity, metabolite and intermediate we list for Vildagliptin.

Vildagliptin impurities

Specifications & identifiers

Chemical identifiers
Product name	Cyclo-(Pro-Gly)
Catalogue No.	VQ-039651
CAS Number	19179-12-5
IUPAC name	2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Molecular formula	C₇H₁₀N₂O₂
Molecular weight	154.17 g/mol
Exact mass	154.0742
Grade	Reference Standard
HSN code	38229090
InChIKey	OWOHLURDBZHNGG-UHFFFAOYSA-N
SMILES	C1CC2C(=O)NCC(=O)N2C1
PubChem CID	193540

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.6
H-bond donors / acceptors	1 / 2
TPSA	49.4 Å²
Synonyms	Cyclo(glycylprolyl), Cyclo(gly-pro), Cyclo(gly-O-pro), Hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, octahydropyrrolo[1,2-a]piperazine-1,4-dione, Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-, Cyclo(glycyl-L-prolyl), Octahydropyrrolo[1,2-a]pyrazine-1,4-dione, Hexahydropyrrolo[12-a]pyrazine-14-dione, Pyrrolidino[1,2-a]piperazine-3,6-dione, Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-, (S)-

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Cyclo-(Pro-Gly)?

The CAS Registry Number of Cyclo-(Pro-Gly) is 19179-12-5. It is also known as Cyclo(glycylprolyl), Cyclo(gly-pro), Cyclo(gly-O-pro).

What is the molecular formula and molecular weight of Cyclo-(Pro-Gly)?

Cyclo-(Pro-Gly) has the molecular formula C7H10N2O2 and a molecular weight of 154.17 g/mol. Its IUPAC name is 2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione.

What is Cyclo-(Pro-Gly) used for?

Cyclo-(Pro-Gly) is supplied as a characterised reference material related to Vildagliptin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Cyclo-(Pro-Gly) can I order?

We supply Cyclo-(Pro-Gly) in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Cyclo-(Pro-Gly)?

Yes. Every lot of Cyclo-(Pro-Gly) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Cyclo-(Pro-Gly) be shipped internationally?

Yes. Cyclo-(Pro-Gly) is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.