1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine 2089333-01-5

About 1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine

1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine is a nitrosamine impurity of Brigatinib carrying the CAS registry number 2089333-01-5. The compound has the formula C10H20N4O, corresponding to a molecular weight of 212.29 g/mol.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Danger” with 6 hazard statements. Review the Safety Data Sheet before use.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Brigatinib, method validation (AMV) and regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer 1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Brigatinib

View every impurity, metabolite and intermediate we list for Brigatinib.

Brigatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine
Catalogue No.	VQ-042995
CAS Number	2089333-01-5
IUPAC name	1-methyl-4-(1-nitrosopiperidin-4-yl)piperazine
Molecular formula	C₁₀H₂₀N₄O
Molecular weight	212.29 g/mol
Exact mass	212.1637
Grade	Reference Standard
HSN code	38229090
InChIKey	LNPJNCLQKONMLZ-UHFFFAOYSA-N
SMILES	CN1CCN(CC1)C2CCN(CC2)N=O
PubChem CID	126705144

Physical properties
Physical form	Solid
LogP (XLogP3)	0.6
H-bond donors / acceptors	0 / 5
TPSA	39.2 Å²

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H332Harmful if inhaled
H335May cause respiratory irritation
H350May cause cancer

Precautionary statements: P203, P260, P261, P264, P270, P271, P280, P301 + P317, P301 + P330 + P331, P302 + P352, P302 + P361 + P354, P304 + P340, P305 + P354 + P338, P316, P317, P318, P319, P321, P330, P362 + P364, P363, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine?

The CAS Registry Number of 1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine is 2089333-01-5.

What is the molecular formula and molecular weight of 1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine?

1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine has the molecular formula C10H20N4O and a molecular weight of 212.29 g/mol. Its IUPAC name is 1-methyl-4-(1-nitrosopiperidin-4-yl)piperazine.

What is 1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine used for?

1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine is supplied as a characterised reference material related to Brigatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine can I order?

We supply 1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine?

Yes. Every lot of 1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine be shipped internationally?

Yes. 1-Methyl-4-(1-nitrosopiperidin-4-yl)piperazine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.