Pirtobrutinib

Name: Pirtobrutinib
Brand: Vaqora Chemicals
SKU: VQ-033221

About Pirtobrutinib

Vaqora Chemicals supplies Pirtobrutinib, a high-purity reference standard of Pirtobrutinib registered under CAS number 2101700-15-4. With the molecular formula C22H21F4N5O3, it has a molar mass of 479.4 g/mol. Common synonyms include LOXO-305 and RXC-005.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Danger” with 3 hazard statements. Review the Safety Data Sheet before use.

As a reference sample of Pirtobrutinib, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Pirtobrutinib is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Pirtobrutinib

View every impurity, metabolite and intermediate we list for Pirtobrutinib.

Pirtobrutinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Pirtobrutinib
Catalogue No.	VQ-033221
CAS Number	2101700-15-4
IUPAC name	5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(2S)-1,1,1-trifluoropropan-2-yl]pyrazole-4-carboxamide
Molecular formula	C₂₂H₂₁F₄N₅O₃
Molecular weight	479.4 g/mol
Exact mass	479.1581
Grade	Reference Standard
HSN code	38229090
InChIKey	FWZAWAUZXYCBKZ-NSHDSACASA-N
SMILES	C[C@@H](C(F)(F)F)N1C(=C(C(=N1)C2=CC=C(C=C2)CNC(=O)C3=C(C=CC(=C3)F)OC)C(=O)N)N
PubChem CID	129269915

Physical properties
Physical form	Solid
LogP (XLogP3)	3.3
H-bond donors / acceptors	3 / 9
TPSA	125 Å²
Synonyms	LOXO-305, RXC-005, LOXO 305, BTK Inhibitor LOXO-305, BTK inhibitor 16, EX-A5016

Safety & hazard information (GHS)

Health hazard

Environmental hazard

Signal word: Danger

Hazard statements

H360May damage fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P273, P280, P318, P319, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Pirtobrutinib?

The CAS Registry Number of Pirtobrutinib is 2101700-15-4. It is also known as LOXO-305, RXC-005, LOXO 305.

What is the molecular formula and molecular weight of Pirtobrutinib?

Pirtobrutinib has the molecular formula C22H21F4N5O3 and a molecular weight of 479.4 g/mol. Its IUPAC name is 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(2S)-1,1,1-trifluoropropan-2-yl]pyrazole-4-carboxamide.

What is Pirtobrutinib used for?

Pirtobrutinib is supplied as a characterised reference material related to Pirtobrutinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Pirtobrutinib can I order?

We supply Pirtobrutinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Pirtobrutinib?

Yes. Every lot of Pirtobrutinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Pirtobrutinib be shipped internationally?

Yes. Pirtobrutinib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.