Selpercatinib

Name: Selpercatinib
Brand: Vaqora Chemicals
SKU: VQ-028000

About Selpercatinib

Vaqora Chemicals supplies Selpercatinib, a high-purity reference standard of Selpercatinib registered under CAS number 2152628-33-4. The compound has the formula C29H31N7O3, corresponding to a molecular weight of 525.6 g/mol. It is also known as Ret inhibitor loxo-292 or RET Kinase Inhibitor LOXO-292.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Selpercatinib, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Selpercatinib in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Selpercatinib

View every impurity, metabolite and intermediate we list for Selpercatinib.

Selpercatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Selpercatinib
Catalogue No.	VQ-028000
CAS Number	2152628-33-4
IUPAC name	6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile
Molecular formula	C₂₉H₃₁N₇O₃
Molecular weight	525.6 g/mol
Exact mass	525.2488
Grade	Reference Standard
HSN code	38229090
InChIKey	XIIOFHFUYBLOLW-UHFFFAOYSA-N
SMILES	CC(C)(COC1=CN2C(=C(C=N2)C#N)C(=C1)C3=CN=C(C=C3)N4CC5CC(C4)N5CC6=CN=C(C=C6)OC)O
PubChem CID	134436906

Physical properties
Physical form	Solid
LogP (XLogP3)	2.5
H-bond donors / acceptors	1 / 9
TPSA	112 Å²
Synonyms	Ret inhibitor loxo-292, RET Kinase Inhibitor LOXO-292, Loxo-292, Selpercatinib (LOXO-292), US10112942, Example 163, US10112942, Example 166, Selpercatinib(LOXO-292), LOXO-292 (Selpercatinib), EX-A2859, US10112942, Example 183, example 163 [WO2018071447A1]

Safety & hazard information (GHS)

Health hazard

Environmental hazard

Signal word: Danger

Hazard statements

H341Suspected of causing genetic defects
H360May damage fertility or the unborn child
H371May cause damage to organs
H373May causes damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P264, P270, P273, P280, P308 + P316, P318, P319, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Selpercatinib?

The CAS Registry Number of Selpercatinib is 2152628-33-4. It is also known as Ret inhibitor loxo-292, RET Kinase Inhibitor LOXO-292, Loxo-292.

What is the molecular formula and molecular weight of Selpercatinib?

Selpercatinib has the molecular formula C29H31N7O3 and a molecular weight of 525.6 g/mol. Its IUPAC name is 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile.

What is Selpercatinib used for?

Selpercatinib is supplied as a characterised reference material related to Selpercatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Selpercatinib can I order?

We supply Selpercatinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Selpercatinib?

Yes. Every lot of Selpercatinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Selpercatinib be shipped internationally?

Yes. Selpercatinib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.