N-Boc-N-nitro-L-arginine

Name: N-Boc-N-nitro-L-arginine
Brand: Vaqora Chemicals
SKU: VQ-032601

About N-Boc-N-nitro-L-arginine

Vaqora Chemicals supplies N-Boc-N-nitro-L-arginine, a nitrosamine impurity of Argatroban registered under CAS number 2188-18-3. Formula C11H21N5O6, molecular weight 319.31 g/mol. Its systematic (IUPAC) name is (2S)-5-[[amino(nitramido)methylidene]amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid. Common synonyms include Boc-L-Nitroarginine and Boc-Arg(NO2)-OH.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Argatroban, method validation (AMV) and regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Argatroban

View every impurity, metabolite and intermediate we list for Argatroban.

Argatroban impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Boc-N-nitro-L-arginine
Catalogue No.	VQ-032601
CAS Number	2188-18-3
IUPAC name	(2S)-5-[[amino(nitramido)methylidene]amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid
Molecular formula	C₁₁H₂₁N₅O₆
Molecular weight	319.31 g/mol
Exact mass	319.1492
Grade	Reference Standard
HSN code	38229090
InChIKey	OZSSOVRIEPAIMP-ZETCQYMHSA-N
SMILES	CC(C)(C)OC(=O)N[C@@H](CCCN=C(N)N[N+](=O)[O-])C(=O)O
PubChem CID	75141

Physical properties
Physical form	Solid
LogP (XLogP3)	0.3
H-bond donors / acceptors	4 / 7
TPSA	172 Å²
Synonyms	Boc-L-Nitroarginine, L-Ornithine, N2-((1,1-dimethylethoxy)carbonyl)-N5-(imino(nitroamino)methyl)-, L-Ornithine, N2-[(1,1-dimethylethoxy)carbonyl]-N5-[imino(nitroamino)methyl]-, N2-((1,1-Dimethylethoxy)carbonyl)-N5-(imino(nitroamino)methyl)-L-ornithine, N2-[(1,1-dimethylethoxy)carbonyl]-N5-[imino(nitroamino)methyl]-L-ornithine, Boc-Arg(NO2)-OH, BOC-L-Arg(NO2)-OH, N2-(tert-Butoxycarbonyl)-Nw-nitro-L-arginine, Boc-Arg(NO)-OH, (S)-2-((tert-Butoxycarbonyl)amino)-5-(3-nitroguanidino)pentanoic acid, Boc Arg(NO2)OH

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H336May cause drowsiness or dizziness

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Boc-N-nitro-L-arginine?

The CAS Registry Number of N-Boc-N-nitro-L-arginine is 2188-18-3. It is also known as Boc-L-Nitroarginine, L-Ornithine, N2-((1,1-dimethylethoxy)carbonyl)-N5-(imino(nitroamino)methyl)-, L-Ornithine, N2-[(1,1-dimethylethoxy)carbonyl]-N5-[imino(nitroamino)methyl]-.

What is the molecular formula and molecular weight of N-Boc-N-nitro-L-arginine?

N-Boc-N-nitro-L-arginine has the molecular formula C11H21N5O6 and a molecular weight of 319.31 g/mol. Its IUPAC name is (2S)-5-[[amino(nitramido)methylidene]amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid.

What is N-Boc-N-nitro-L-arginine used for?

N-Boc-N-nitro-L-arginine is supplied as a characterised reference material related to Argatroban. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Boc-N-nitro-L-arginine can I order?

We supply N-Boc-N-nitro-L-arginine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Boc-N-nitro-L-arginine?

Yes. Every lot of N-Boc-N-nitro-L-arginine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Boc-N-nitro-L-arginine be shipped internationally?

Yes. N-Boc-N-nitro-L-arginine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.