4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl… 2254541-79-0

Name: 4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile
Brand: Vaqora Chemicals
SKU: VQ-025090

About 4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile

4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile (CAS 2254541-79-0) is a metabolite or degradation product of Crisaborole offered by Vaqora Chemicals. Formula C28H20N2O4, molecular weight 448.5 g/mol. Its systematic (IUPAC) name is 4-[4-[4-(4-cyanophenoxy)-2-(hydroxymethyl)phenyl]-3-(hydroxymethyl)phenoxy]benzonitrile. Common synonyms include Crisaborole diamer and Crisaborole Dimer.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Crisaborole, as well as in QC testing and ANDA/DMF documentation. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Crisaborole

View every impurity, metabolite and intermediate we list for Crisaborole.

Crisaborole impurities

Specifications & identifiers

Chemical identifiers
Product name	4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile
Catalogue No.	VQ-025090
CAS Number	2254541-79-0
IUPAC name	4-[4-[4-(4-cyanophenoxy)-2-(hydroxymethyl)phenyl]-3-(hydroxymethyl)phenoxy]benzonitrile
Molecular formula	C₂₈H₂₀N₂O₄
Molecular weight	448.5 g/mol
Exact mass	448.1423
Grade	Reference Standard
HSN code	38229090
InChIKey	UWNXSZBSYAINRD-UHFFFAOYSA-N
SMILES	C1=CC(=CC=C1C#N)OC2=CC(=C(C=C2)C3=C(C=C(C=C3)OC4=CC=C(C=C4)C#N)CO)CO
PubChem CID	142489955

Physical properties
Physical form	Solid
LogP (XLogP3)	4.3
H-bond donors / acceptors	2 / 6
TPSA	107 Å²
Synonyms	Crisaborole diamer, Benzonitrile, 4,4'-((2,2'-bis(hydroxymethyl)(1,1'-biphenyl)-4,4'-diyl)bis(oxy))bis-, Crisaborole Dimer, Benzonitrile, 4,4'-[[2,2'-bis(hydroxymethyl)[1,1'-biphenyl]-4,4'-diyl]bis(oxy)]bis-, 4,4'-[[2,2'-Bis(hydroxymethyl)[1,1'-biphenyl]-4,4'-diyl]bis(oxy)]bis[benzonitrile]

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile?

The CAS Registry Number of 4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile is 2254541-79-0. It is also known as Crisaborole diamer, Benzonitrile, 4,4'-((2,2'-bis(hydroxymethyl)(1,1'-biphenyl)-4,4'-diyl)bis(oxy))bis-, Crisaborole Dimer.

What is the molecular formula and molecular weight of 4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile?

4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile has the molecular formula C28H20N2O4 and a molecular weight of 448.5 g/mol. Its IUPAC name is 4-[4-[4-(4-cyanophenoxy)-2-(hydroxymethyl)phenyl]-3-(hydroxymethyl)phenoxy]benzonitrile.

What is 4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile used for?

4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile is supplied as a characterised reference material related to Crisaborole. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile can I order?

We supply 4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile?

Yes. Every lot of 4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile be shipped internationally?

Yes. We export 4,4'-((2,2'-Bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.