Dexamethasone isonicotinate

About Dexamethasone isonicotinate

Dexamethasone isonicotinate is an impurity of Dexamethasone carrying the CAS registry number 2265-64-7. The compound has the formula C28H32FNO6, corresponding to a molecular weight of 497.6 g/mol. It is also known as Dexamethasone 21-isonicotinate or HE 111.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

This Dexamethasone impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer Dexamethasone isonicotinate in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Dexamethasone

View every impurity, metabolite and intermediate we list for Dexamethasone.

Dexamethasone impurities

Specifications & identifiers

Chemical identifiers
Product name	Dexamethasone isonicotinate
Catalogue No.	VQ-030149
CAS Number	2265-64-7
IUPAC name	[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] pyridine-4-carboxylate
Molecular formula	C₂₈H₃₂FNO₆
Molecular weight	497.6 g/mol
Exact mass	497.2214
Grade	Reference Standard
HSN code	38229090
InChIKey	BQTXJHAJMDGOFI-NJLPOHDGSA-N
SMILES	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C5=CC=NC=C5)O)C)O)F)C
PubChem CID	16752

Physical properties
Physical form	Solid
LogP (XLogP3)	3.4
H-bond donors / acceptors	2 / 8
TPSA	114 Å²
Synonyms	Dexamethasone 21-isonicotinate, HE 111, Dexamethasone 21-(4-Pyridinecarboxylate), Isonicotinate, Dexamethasone, dexamethasone-21-isonicotinate, Auxilsone, Pyridine-4-carboxylic acid-(dexamethasone-21') ester, Pyridin-4-carbonsaeure-(dexamethason-21')-ester

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Danger

Hazard statements

H302+H312+H332Harmful if swallowed, in contact with skin or if inhaled
H361Suspected of damaging fertility or the unborn child
H362May cause harm to breast-fed children
H373May causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P261, P263, P264, P270, P271, P273, P280, P301 + P317, P302 + P352, P304 + P340, P317, P318, P319, P321, P330, P362 + P364, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Dexamethasone isonicotinate?

The CAS Registry Number of Dexamethasone isonicotinate is 2265-64-7. It is also known as Dexamethasone 21-isonicotinate, HE 111, Dexamethasone 21-(4-Pyridinecarboxylate).

What is the molecular formula and molecular weight of Dexamethasone isonicotinate?

Dexamethasone isonicotinate has the molecular formula C28H32FNO6 and a molecular weight of 497.6 g/mol.

What is Dexamethasone isonicotinate used for?

Dexamethasone isonicotinate is supplied as a characterised reference material related to Dexamethasone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Dexamethasone isonicotinate can I order?

We supply Dexamethasone isonicotinate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Dexamethasone isonicotinate?

Yes. Every lot of Dexamethasone isonicotinate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Dexamethasone isonicotinate be shipped internationally?

Yes. Dexamethasone isonicotinate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.