(S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine 228244-04-0

Name: (S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine
Brand: Vaqora Chemicals
SKU: VQ-039217

About (S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine

Listed under CAS 228244-04-0, (S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine is an impurity of Vildagliptin available from Vaqora Chemicals. With the molecular formula C10H16N2O2, it has a molar mass of 196.25 g/mol. Its systematic (IUPAC) name is tert-butyl (2S)-2-cyanopyrrolidine-1-carboxylate. It is also known as (S)-(-)-1-Boc-2-cyanopyrrolidine or (S)-1-Boc-2-cyanopyrrolidine.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Vildagliptin to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies (S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Vildagliptin

View every impurity, metabolite and intermediate we list for Vildagliptin.

Vildagliptin impurities

Specifications & identifiers

Chemical identifiers
Product name	(S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine
Catalogue No.	VQ-039217
CAS Number	228244-04-0
IUPAC name	tert-butyl (2S)-2-cyanopyrrolidine-1-carboxylate
Molecular formula	C₁₀H₁₆N₂O₂
Molecular weight	196.25 g/mol
Exact mass	196.1212
Grade	Reference Standard
HSN code	38229090
InChIKey	MDMSZBHMBCNYNO-QMMMGPOBSA-N
SMILES	CC(C)(C)OC(=O)N1CCC[C@H]1C#N
PubChem CID	6951263

Physical properties
Physical form	Solid
LogP (XLogP3)	1.4
H-bond donors / acceptors	0 / 3
TPSA	53.3 Å²
Synonyms	(S)-(-)-1-Boc-2-cyanopyrrolidine, (S)-1-Boc-2-cyanopyrrolidine, (S)-tert-butyl 2-cyanopyrrolidine-1-carboxylate, (S)-(-)-1-Boc-2-pyrrolidinecarbonitrile, (S)-1-Boc-2-pyrrolidinecarbonitrile, tert-butyl (S)-2-cyanopyrrolidine-1-carboxylate, BOC-2(S)-cyanopyrrolidine, (S)-1-(tert-Butoxycarbonyl)-2-pyrrolidinecarbonitrile, 1-N-Boc-2- pyrrolidinonitrile, Boc-(S)-pyrrolidine-2-carbonitrile, (S)-1-Boc-pyrrolidine-2-carbonitrile, t-butyl (s)-2-cyanopyrrolidine-1-carboxylate

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302+H312+H332Harmful if swallowed, in contact with skin or if inhaled
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine?

The CAS Registry Number of (S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine is 228244-04-0. It is also known as (S)-(-)-1-Boc-2-cyanopyrrolidine, (S)-1-Boc-2-cyanopyrrolidine, (S)-tert-butyl 2-cyanopyrrolidine-1-carboxylate.

What is the molecular formula and molecular weight of (S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine?

(S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine has the molecular formula C10H16N2O2 and a molecular weight of 196.25 g/mol. Its IUPAC name is tert-butyl (2S)-2-cyanopyrrolidine-1-carboxylate.

What is (S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine used for?

(S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine is supplied as a characterised reference material related to Vildagliptin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine can I order?

We supply (S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine?

Yes. Every lot of (S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine be shipped internationally?

Yes. (S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.