Threono-1,4-lactone

About Threono-1,4-lactone

Threono-1,4-lactone is an impurity of Ascorbic acid carrying the CAS registry number 23732-41-4. With the molecular formula C4H6O4, it has a molar mass of 118.09 g/mol. The IUPAC name is (3S,4R)-3,4-dihydroxyoxolan-2-one. It is also known as D-Threonic acid-1,4,-lactone or D-threonolactone.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Pharmaceutical QC and development laboratories use this impurity standard of Ascorbic acid to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Threono-1,4-lactone is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Ascorbic acid

View every impurity, metabolite and intermediate we list for Ascorbic acid.

Ascorbic acid impurities

Specifications & identifiers

Chemical identifiers
Product name	Threono-1,4-lactone
Catalogue No.	VQ-040353
CAS Number	23732-41-4
IUPAC name	(3S,4R)-3,4-dihydroxyoxolan-2-one
Molecular formula	C₄H₆O₄
Molecular weight	118.09 g/mol
Exact mass	118.0266
Grade	Reference Standard
HSN code	38229090
InChIKey	SGMJBNSHAZVGMC-GBXIJSLDSA-N
SMILES	C1[C@H]([C@@H](C(=O)O1)O)O
PubChem CID	10351686

Physical properties
Physical form	Solid
LogP (XLogP3)	-1.3
H-bond donors / acceptors	2 / 4
TPSA	66.8 Å²
Synonyms	D-Threonic acid-1,4,-lactone, D-threonolactone, GlyTouCan:G54590PA, (3S,4R)-3,4-dihydroxydihydrofuran-2(3H)-one, D-threono-1,4-lactone, d-threonic acid-1,4-lactone

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Threono-1,4-lactone?

The CAS Registry Number of Threono-1,4-lactone is 23732-41-4. It is also known as D-Threonic acid-1,4,-lactone, D-threonolactone, GlyTouCan:G54590PA.

What is the molecular formula and molecular weight of Threono-1,4-lactone?

Threono-1,4-lactone has the molecular formula C4H6O4 and a molecular weight of 118.09 g/mol. Its IUPAC name is (3S,4R)-3,4-dihydroxyoxolan-2-one.

What is Threono-1,4-lactone used for?

Threono-1,4-lactone is supplied as a characterised reference material related to Ascorbic acid. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Threono-1,4-lactone can I order?

We supply Threono-1,4-lactone in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Threono-1,4-lactone?

Yes. Every lot of Threono-1,4-lactone is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Threono-1,4-lactone be shipped internationally?

Yes. We export Threono-1,4-lactone worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.