Thyrotropin-Releasing Hormone (TRH)

Name: Thyrotropin-Releasing Hormone (TRH)
Brand: Vaqora Chemicals
SKU: VQ-043563

About Thyrotropin-Releasing Hormone (TRH)

Thyrotropin-Releasing Hormone (TRH) is an impurity of Protirelin carrying the CAS registry number 24305-27-9. The compound has the formula C16H22N6O4, corresponding to a molecular weight of 362.38 g/mol. Common synonyms include Protirelin and Thyroliberin.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Protirelin to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Thyrotropin-Releasing Hormone (TRH) in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Protirelin

View every impurity, metabolite and intermediate we list for Protirelin.

Protirelin impurities

Specifications & identifiers

Chemical identifiers
Product name	Thyrotropin-Releasing Hormone (TRH)
Catalogue No.	VQ-043563
CAS Number	24305-27-9
IUPAC name	(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular formula	C₁₆H₂₂N₆O₄
Molecular weight	362.38 g/mol
Exact mass	362.1703
Grade	Reference Standard
HSN code	38229090
InChIKey	XNSAINXGIQZQOO-SRVKXCTJSA-N
SMILES	C1C[C@H](N(C1)C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@@H]3CCC(=O)N3)C(=O)N
PubChem CID	638678

Physical properties
Physical form	Solid
LogP (XLogP3)	-2.5
H-bond donors / acceptors	4 / 5
TPSA	150 Å²
Synonyms	Protirelin, Thyroliberin, Lopremone, Synthetic TRH, Rifathyroin, Thypinone, Thyrotropin-releasing factor, TSH-releasing factor, Protireline, Thyrotropic-releasing factor, 5-Oxo-L-prolyl-L-histidyl-L-prolinamide, Synthetic tsh-releasing factor

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H332Harmful if inhaled

Precautionary statements: P261, P271, P304 + P340, P317

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Thyrotropin-Releasing Hormone (TRH)?

The CAS Registry Number of Thyrotropin-Releasing Hormone (TRH) is 24305-27-9. It is also known as Protirelin, Thyroliberin, Lopremone.

What is the molecular formula and molecular weight of Thyrotropin-Releasing Hormone (TRH)?

Thyrotropin-Releasing Hormone (TRH) has the molecular formula C16H22N6O4 and a molecular weight of 362.38 g/mol. Its IUPAC name is (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide.

What is Thyrotropin-Releasing Hormone (TRH) used for?

Thyrotropin-Releasing Hormone (TRH) is supplied as a characterised reference material related to Protirelin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Thyrotropin-Releasing Hormone (TRH) can I order?

We supply Thyrotropin-Releasing Hormone (TRH) in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Thyrotropin-Releasing Hormone (TRH)?

Yes. Every lot of Thyrotropin-Releasing Hormone (TRH) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Thyrotropin-Releasing Hormone (TRH) be shipped internationally?

Yes. Thyrotropin-Releasing Hormone (TRH) is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.