5-Methoxyindole-3-acetonitrile

About 5-Methoxyindole-3-acetonitrile

5-Methoxyindole-3-acetonitrile is an impurity of Melatonin carrying the CAS registry number 2436-17-1. Its molecular formula is C11H10N2O and its molecular weight is 186.21 g/mol. The IUPAC name is 2-(5-methoxy-1H-indol-3-yl)acetonitrile. Alternative names: 5-Methoxy-3-indolylacetonitrile and (5-methoxy-1H-indol-3-yl)acetonitrile.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Melatonin, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 5-Methoxyindole-3-acetonitrile is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Melatonin

View every impurity, metabolite and intermediate we list for Melatonin.

Melatonin impurities

Specifications & identifiers

Chemical identifiers
Product name	5-Methoxyindole-3-acetonitrile
Catalogue No.	VQ-035430
CAS Number	2436-17-1
IUPAC name	2-(5-methoxy-1H-indol-3-yl)acetonitrile
Molecular formula	C₁₁H₁₀N₂O
Molecular weight	186.21 g/mol
Exact mass	186.0793
Grade	Reference Standard
HSN code	38229090
InChIKey	ZBQCXEREMRGOCO-UHFFFAOYSA-N
SMILES	COC1=CC2=C(C=C1)NC=C2CC#N
PubChem CID	3564783

Physical properties
Physical form	Solid
LogP (XLogP3)	1.7
H-bond donors / acceptors	1 / 2
TPSA	48.8 Å²
Synonyms	5-Methoxy-3-indolylacetonitrile, (5-methoxy-1H-indol-3-yl)acetonitrile, 2-(5-methoxy-1~{H}-indol-3-yl)ethanenitrile, 2-(5-methoxyindol-3-yl)ethanenitrile, (5-methoxy-3-indolyl)-acetonitrile, (5-methoxy-1H-indol-3-yl)-acetonitrile

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302+H312+H332Harmful if swallowed, in contact with skin or if inhaled
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 5-Methoxyindole-3-acetonitrile?

The CAS Registry Number of 5-Methoxyindole-3-acetonitrile is 2436-17-1. It is also known as 5-Methoxy-3-indolylacetonitrile, (5-methoxy-1H-indol-3-yl)acetonitrile, 2-(5-methoxy-1~{H}-indol-3-yl)ethanenitrile.

What is the molecular formula and molecular weight of 5-Methoxyindole-3-acetonitrile?

5-Methoxyindole-3-acetonitrile has the molecular formula C11H10N2O and a molecular weight of 186.21 g/mol. Its IUPAC name is 2-(5-methoxy-1H-indol-3-yl)acetonitrile.

What is 5-Methoxyindole-3-acetonitrile used for?

5-Methoxyindole-3-acetonitrile is supplied as a characterised reference material related to Melatonin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 5-Methoxyindole-3-acetonitrile can I order?

We supply 5-Methoxyindole-3-acetonitrile in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 5-Methoxyindole-3-acetonitrile?

Yes. Every lot of 5-Methoxyindole-3-acetonitrile is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 5-Methoxyindole-3-acetonitrile be shipped internationally?

Yes. 5-Methoxyindole-3-acetonitrile is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.