Dapivirine

About Dapivirine

Dapivirine is a high-purity reference standard of Dapivirine carrying the CAS registry number 244767-67-7. Formula C20H19N5, molecular weight 329.4 g/mol. Systematically, it is named 4-[[4-(2,4,6-trimethylanilino)pyrimidin-2-yl]amino]benzonitrile. Common synonyms include TMC-120 and TMC 120.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Dapivirine, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Dapivirine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Dapivirine

View every impurity, metabolite and intermediate we list for Dapivirine.

Dapivirine impurities

Specifications & identifiers

Chemical identifiers
Product name	Dapivirine
Catalogue No.	VQ-030029
CAS Number	244767-67-7
IUPAC name	4-[[4-(2,4,6-trimethylanilino)pyrimidin-2-yl]amino]benzonitrile
Molecular formula	C₂₀H₁₉N₅
Molecular weight	329.4 g/mol
Exact mass	329.164
Grade	Reference Standard
HSN code	38229090
InChIKey	ILAYIAGXTHKHNT-UHFFFAOYSA-N
SMILES	CC1=CC(=C(C(=C1)C)NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C
PubChem CID	214347

Physical properties
Physical form	Solid
LogP (XLogP3)	4.8
H-bond donors / acceptors	2 / 5
TPSA	73.6 Å²
Synonyms	TMC-120, TMC 120, Gel-02, 4-({4-[(2,4,6-trimethylphenyl)amino]pyrimidin-2-yl}amino)benzonitrile, 4-((4-((2,4,6-Trimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile, 4-((4-((2,4,6-trimethylphenyl)amino)-2-pyrimidinyl)amino) benzonitrile, Dapivirine (TMC120), Benzonitrile, 4-[[4-[(2,4,6-trimethylphenyl)amino]-2-pyrimidinyl]amino]-, Dapivirine,tmc-120, 4-[[4-[(2,4,6-trimethylphenyl)amino]-2-pyrimidinyl]amino]benzonitrile, 4-((4-(mesitylamino)pyrimidin-2-yl)amino)benzonitrile, 4-[[4-(Mesitylamino)pyrimidin-2-yl]amino]benzonitrile

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Dapivirine?

The CAS Registry Number of Dapivirine is 244767-67-7. It is also known as TMC-120, TMC 120, Gel-02.

What is the molecular formula and molecular weight of Dapivirine?

Dapivirine has the molecular formula C20H19N5 and a molecular weight of 329.4 g/mol. Its IUPAC name is 4-[[4-(2,4,6-trimethylanilino)pyrimidin-2-yl]amino]benzonitrile.

What is Dapivirine used for?

Dapivirine is supplied as a characterised reference material related to Dapivirine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Dapivirine can I order?

We supply Dapivirine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Dapivirine?

Yes. Every lot of Dapivirine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Dapivirine be shipped internationally?

Yes. Dapivirine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.