Varenicline

Name: Varenicline
Brand: Vaqora Chemicals
SKU: VQ-007838

About Varenicline

Listed under CAS 249296-44-4, Varenicline is a high-purity reference standard of Varenicline available from Vaqora Chemicals. With the molecular formula C13H13N3, it has a molar mass of 211.26 g/mol. Systematically, it is named (1S,12R)-5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaene. It is also known as Champix or US9284322, varenicline.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 2 hazard statements. Review the Safety Data Sheet before use.

Laboratories use this Varenicline standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. Stock is available for quick dispatch.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Varenicline

View every impurity, metabolite and intermediate we list for Varenicline.

Varenicline impurities

Specifications & identifiers

Chemical identifiers
Product name	Varenicline
Catalogue No.	VQ-007838
CAS Number	249296-44-4
IUPAC name	(1S,12R)-5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaene
Molecular formula	C₁₃H₁₃N₃
Molecular weight	211.26 g/mol
Exact mass	211.1109
Grade	Reference Standard
HSN code	38229090
InChIKey	JQSHBVHOMNKWFT-DTORHVGOSA-N
SMILES	C1[C@@H]2CNC[C@H]1C3=CC4=NC=CN=C4C=C23
PubChem CID	5310966

Physical properties
Physical form	Solid
LogP (XLogP3)	0.8
H-bond donors / acceptors	1 / 3
TPSA	37.8 Å²
Synonyms	(6R,10S)-7,8,9,10-Tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline, 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine, Champix, 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine, (1R,12S)-5,8,14-triazatetracyclo[10.3.1.0^{2,11}.0^{4,9}]hexadeca-2(11),3,5,7,9-pentaene, (1R,12S)-5,8,14-triazatetracyclo(10.3.1.0^(2,11).0^(4,9))hexadeca-2(11),3,5,7,9-pentaene, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino(2,3-h)benzazepine, (1R,12S)-5,8,14-triazatetracyclo(10.3.1.02,11.04,9)hexadeca-2,4,6,8,10-pentaene, 6,10-Methano-6H-pyrazino(2,3-h)(3)benzazepine, 7,8,9,10-tetrahydro-, 7,8,9,10-tetrahydro-6H-6,10-methanoazepino(4,5-g)quinoxaline, US9284322, varenicline, compound 9a [PMID: 16171993]

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H400Very toxic to aquatic life

Precautionary statements: P264, P270, P273, P301 + P317, P330, P391, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Varenicline?

The CAS Registry Number of Varenicline is 249296-44-4. It is also known as (6R,10S)-7,8,9,10-Tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline, 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine, Champix.

What is the molecular formula and molecular weight of Varenicline?

Varenicline has the molecular formula C13H13N3 and a molecular weight of 211.26 g/mol. Its IUPAC name is (1S,12R)-5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaene.

What is Varenicline used for?

Varenicline is supplied as a characterised reference material related to Varenicline. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Varenicline can I order?

We supply Varenicline in Reference Standard grade, in 10 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Varenicline?

Yes. Every lot of Varenicline is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Varenicline be shipped internationally?

Yes. Varenicline is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.