4-Hydroxy-3-methoxyphenylacetone

About 4-Hydroxy-3-methoxyphenylacetone

4-Hydroxy-3-methoxyphenylacetone is a metabolite or degradation product of Fludarabine carrying the CAS registry number 2503-46-0. Formula C10H12O3, molecular weight 180.2 g/mol. Its systematic (IUPAC) name is 1-(4-hydroxy-3-methoxyphenyl)propan-2-one. It is also known as Guaiacylacetone or 2-Propanone, 1-(4-hydroxy-3-methoxyphenyl)-.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Analytical teams use this compound to identify metabolites and degradants of Fludarabine, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer 4-Hydroxy-3-methoxyphenylacetone in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Fludarabine

View every impurity, metabolite and intermediate we list for Fludarabine.

Fludarabine impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Hydroxy-3-methoxyphenylacetone
Catalogue No.	VQ-050509
CAS Number	2503-46-0
IUPAC name	1-(4-hydroxy-3-methoxyphenyl)propan-2-one
Molecular formula	C₁₀H₁₂O₃
Molecular weight	180.2 g/mol
Exact mass	180.0786
Grade	Reference Standard
HSN code	38229090
InChIKey	LFVCJQWZGDLHSD-UHFFFAOYSA-N
SMILES	CC(=O)CC1=CC(=C(C=C1)O)OC
PubChem CID	17262

Physical properties
Physical form	Solid
LogP (XLogP3)	0.5
H-bond donors / acceptors	1 / 3
TPSA	46.5 Å²
Synonyms	Guaiacylacetone, 2-Propanone, 1-(4-hydroxy-3-methoxyphenyl)-, 4-Hydroxy-3-methoxyphenylpropan-2-one, 1-(4-Hydroxy-3-methoxy-phenyl)-propan-2-one, HMP-one, 2-Propanone, 1-(4-hydroxy-3-methoxyphenyl)-(8CI), 2-Propanone, 1-(4-hydroxy-3-methoxyphenyl)-(8CI)(9CI), Vanillyl methyl ketone, 1-(4-Hydroxy-3-methoxyphenyl)acetone, 2-Propiovanillone, Methyl vanillyl ketone

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Hydroxy-3-methoxyphenylacetone?

The CAS Registry Number of 4-Hydroxy-3-methoxyphenylacetone is 2503-46-0. It is also known as Guaiacylacetone, 2-Propanone, 1-(4-hydroxy-3-methoxyphenyl)-, 4-Hydroxy-3-methoxyphenylpropan-2-one.

What is the molecular formula and molecular weight of 4-Hydroxy-3-methoxyphenylacetone?

4-Hydroxy-3-methoxyphenylacetone has the molecular formula C10H12O3 and a molecular weight of 180.2 g/mol. Its IUPAC name is 1-(4-hydroxy-3-methoxyphenyl)propan-2-one.

What is 4-Hydroxy-3-methoxyphenylacetone used for?

4-Hydroxy-3-methoxyphenylacetone is supplied as a characterised reference material related to Fludarabine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Hydroxy-3-methoxyphenylacetone can I order?

We supply 4-Hydroxy-3-methoxyphenylacetone in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Hydroxy-3-methoxyphenylacetone?

Yes. Every lot of 4-Hydroxy-3-methoxyphenylacetone is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Hydroxy-3-methoxyphenylacetone be shipped internationally?

Yes. 4-Hydroxy-3-methoxyphenylacetone is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.