N-(Carboxymethyl)-N-nitrosoglycine

About N-(Carboxymethyl)-N-nitrosoglycine

N-(Carboxymethyl)-N-nitrosoglycine is a nitrosamine impurity of Dabigatran carrying the CAS registry number 25081-31-6, specified at 98.66% purity. Formula C4H6N2O5, molecular weight 162.1 g/mol. The IUPAC name is 2-[carboxymethyl(nitroso)amino]acetic acid. Common synonyms include N-Nitroso 2,2'-azanediyldiacetic Acid and 2,2'-(Nitrosoazanediyl)diacetic acid.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 5 hazard statements. Review the Safety Data Sheet before use.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Dabigatran, method validation (AMV) and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Dabigatran

View every impurity, metabolite and intermediate we list for Dabigatran.

Dabigatran impurities

Specifications & identifiers

Chemical identifiers
Product name	N-(Carboxymethyl)-N-nitrosoglycine
Catalogue No.	VQ-006863
CAS Number	25081-31-6
IUPAC name	2-[carboxymethyl(nitroso)amino]acetic acid
Molecular formula	C₄H₆N₂O₅
Molecular weight	162.1 g/mol
Exact mass	162.0277
Grade	Reference Standard
Purity / assay	98.66%
HSN code	38229090
InChIKey	XLYVHYXTFHZCNY-UHFFFAOYSA-N
SMILES	C(C(=O)O)N(CC(=O)O)N=O
PubChem CID	32784

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.6
H-bond donors / acceptors	2 / 7
TPSA	107 Å²
Synonyms	N-Nitroso 2,2'-azanediyldiacetic Acid, 2,2'-(Nitrosoazanediyl)diacetic acid, N-Nitrosoiminodiacetic acid, Nitrosoiminodiacetic acid, Glycine, N-(carboxymethyl)-N-nitroso-, N-Nitrosoimidodiacetic acid, 2-[(carboxymethyl)(nitroso)amino]acetic acid, 2,2'-(nitrosoimino)diacetic acid, 2,2'-(Nitrosoimino)bisacetic acid, 3-Azapentanedioic acid, 3-nitroso-, 22'-(Nitrosoazanediyl)diacetic acid

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H351Suspected of causing cancer

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-(Carboxymethyl)-N-nitrosoglycine?

The CAS Registry Number of N-(Carboxymethyl)-N-nitrosoglycine is 25081-31-6. It is also known as N-Nitroso 2,2'-azanediyldiacetic Acid, 2,2'-(Nitrosoazanediyl)diacetic acid, N-Nitrosoiminodiacetic acid.

What is the molecular formula and molecular weight of N-(Carboxymethyl)-N-nitrosoglycine?

N-(Carboxymethyl)-N-nitrosoglycine has the molecular formula C4H6N2O5 and a molecular weight of 162.1 g/mol. Its IUPAC name is 2-[carboxymethyl(nitroso)amino]acetic acid.

What is N-(Carboxymethyl)-N-nitrosoglycine used for?

N-(Carboxymethyl)-N-nitrosoglycine is supplied as a characterised reference material related to Dabigatran. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-(Carboxymethyl)-N-nitrosoglycine can I order?

We supply N-(Carboxymethyl)-N-nitrosoglycine in Reference Standard (98.66%) grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-(Carboxymethyl)-N-nitrosoglycine?

Yes. Every lot of N-(Carboxymethyl)-N-nitrosoglycine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-(Carboxymethyl)-N-nitrosoglycine be shipped internationally?

Yes. N-(Carboxymethyl)-N-nitrosoglycine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.