(R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-dif… 269396-59-0

Name: (R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid
Brand: Vaqora Chemicals
SKU: VQ-042198

About (R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid

(R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid (CAS 269396-59-0) is an impurity of Sitagliptin offered by Vaqora Chemicals. The compound has the formula C15H19F2NO4, corresponding to a molecular weight of 315.31 g/mol. Systematically, it is named (3R)-4-(3,4-difluorophenyl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid. It is also known as Boc-3,4-difluoro-D-beta-homophenylalanine or Boc-D-beta-HPhe(3,4-diF)-OH.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Pharmaceutical QC and development laboratories use this impurity standard of Sitagliptin to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Sitagliptin

View every impurity, metabolite and intermediate we list for Sitagliptin.

Sitagliptin impurities

Specifications & identifiers

Chemical identifiers
Product name	(R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid
Catalogue No.	VQ-042198
CAS Number	269396-59-0
IUPAC name	(3R)-4-(3,4-difluorophenyl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid
Molecular formula	C₁₅H₁₉F₂NO₄
Molecular weight	315.31 g/mol
Exact mass	315.1282
Grade	Reference Standard
HSN code	38229090
InChIKey	XZGBRONJONQTTA-SNVBAGLBSA-N
SMILES	CC(C)(C)OC(=O)N[C@H](CC1=CC(=C(C=C1)F)F)CC(=O)O
PubChem CID	7009791

Physical properties
Physical form	Solid
LogP (XLogP3)	2.6
H-bond donors / acceptors	2 / 6
TPSA	75.6 Å²
Synonyms	Boc-(R)-3-Amino-4-(3,4-difluoro-phenyl)-butyric acid, Boc-(R)-3-Amino-4-(3,4-difluorophenyl)butyric acid, Boc-3,4-difluoro-D-beta-homophenylalanine, boc-(r)-3-amino-4-(3,4-difluorophenyl)-butyric acid, (3R)-3-[(tert-butoxycarbonyl)amino]-4-(3,4-difluorophenyl)butanoic acid, (R)-3,4-Difluoro-b-(Boc-amino)benzenebutanoic acid, Boc-D-beta-HPhe(3,4-diF)-OH, (3R)-3-(tert-butoxycarbonylamino)-4-(3,4-difluorophenyl)butanoic acid, (R)-3-(Boc-amino)-4-(3,4-difluorophenyl)butanoic Acid, (3R)-3-{[(tert-butoxy)carbonyl]amino}-4-(3,4-difluorophenyl)butanoic acid

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid?

The CAS Registry Number of (R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid is 269396-59-0. It is also known as Boc-(R)-3-Amino-4-(3,4-difluoro-phenyl)-butyric acid, Boc-(R)-3-Amino-4-(3,4-difluorophenyl)butyric acid, Boc-3,4-difluoro-D-beta-homophenylalanine.

What is the molecular formula and molecular weight of (R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid?

(R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid has the molecular formula C15H19F2NO4 and a molecular weight of 315.31 g/mol. Its IUPAC name is (3R)-4-(3,4-difluorophenyl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid.

What is (R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid used for?

(R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid is supplied as a characterised reference material related to Sitagliptin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid can I order?

We supply (R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid?

Yes. Every lot of (R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid be shipped internationally?

Yes. We export (R)-3-((tert-Butoxycarbonyl)amino)-4-(3,4-difluorophenyl)butanoic Acid worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.