Abemaciclib Metabolite M18

About Abemaciclib Metabolite M18

Abemaciclib Metabolite M18 is a metabolite or degradation product of Abemaciclib carrying the CAS registry number 2704316-81-2. With the molecular formula C25H28F2N8O, it has a molar mass of 494.5 g/mol. It is also known as LSN3106729 (hydrochloride) or CDK ligand for PROTAC.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Abemaciclib, as well as in QC testing and ANDA/DMF documentation. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Abemaciclib

View every impurity, metabolite and intermediate we list for Abemaciclib.

Abemaciclib impurities

Specifications & identifiers

Chemical identifiers
Product name	Abemaciclib Metabolite M18
Catalogue No.	VQ-035570
CAS Number	2704316-81-2
IUPAC name	[4-fluoro-6-[5-fluoro-2-[[5-(piperazin-1-ylmethyl)-2-pyridinyl]amino]pyrimidin-4-yl]-1-propan-2-ylbenzimidazol-2-yl]methanol
Molecular formula	C₂₅H₂₈F₂N₈O
Molecular weight	494.5 g/mol
Exact mass	494.2354
Grade	Reference Standard
HSN code	38229090
InChIKey	YQMRQLBCUBZXEP-UHFFFAOYSA-N
SMILES	CC(C)N1C2=C(C(=CC(=C2)C3=NC(=NC=C3F)NC4=NC=C(C=C4)CN5CCNCC5)F)N=C1CO
PubChem CID	145925652

Physical properties
Physical form	Solid
LogP (XLogP3)	1.8
H-bond donors / acceptors	3 / 10
TPSA	104 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Abemaciclib Metabolite M18?

The CAS Registry Number of Abemaciclib Metabolite M18 is 2704316-81-2. It is also known as LSN3106729 (hydrochloride), CDK ligand for PROTAC, Abemaciclib Impurity 102.

What is the molecular formula and molecular weight of Abemaciclib Metabolite M18?

Abemaciclib Metabolite M18 has the molecular formula C25H28F2N8O and a molecular weight of 494.5 g/mol. Its IUPAC name is [4-fluoro-6-[5-fluoro-2-[[5-(piperazin-1-ylmethyl)-2-pyridinyl]amino]pyrimidin-4-yl]-1-propan-2-ylbenzimidazol-2-yl]methanol.

What is Abemaciclib Metabolite M18 used for?

Abemaciclib Metabolite M18 is supplied as a characterised reference material related to Abemaciclib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Abemaciclib Metabolite M18 can I order?

We supply Abemaciclib Metabolite M18 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Abemaciclib Metabolite M18?

Yes. Every lot of Abemaciclib Metabolite M18 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Abemaciclib Metabolite M18 be shipped internationally?

Yes. We export Abemaciclib Metabolite M18 worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.