NorDoxepin Hydrochloride

About NorDoxepin Hydrochloride

NorDoxepin Hydrochloride is a metabolite or degradation product of Doxepin carrying the CAS registry number 2887-91-4. The compound has the formula C18H20ClNO, corresponding to a molecular weight of 301.8 g/mol. Common synonyms include Nordoxepin Hydrochloride (E/Z Mixture) and N-Desmethyldoxepin hydrochloride.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 2 hazard statements. Review the Safety Data Sheet before use.

Analytical teams use this compound to identify metabolites and degradants of Doxepin, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer NorDoxepin Hydrochloride in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Doxepin

View every impurity, metabolite and intermediate we list for Doxepin.

Doxepin impurities

Specifications & identifiers

Chemical identifiers
Product name	NorDoxepin Hydrochloride
Catalogue No.	VQ-025393
CAS Number	2887-91-4
IUPAC name	(3Z)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N-methylpropan-1-amine;hydrochloride
Molecular formula	C₁₈H₂₀ClNO
Molecular weight	301.8 g/mol
Exact mass	301.1233
Grade	Reference Standard
HSN code	38229090
InChIKey	GNPPEZGJRSOKRE-HYMQDMCPSA-N
SMILES	CNCC/C=C\1/C2=CC=CC=C2COC3=CC=CC=C31.Cl
PubChem CID	6433350

Physical properties
Physical form	Solid
H-bond donors / acceptors	2 / 2
TPSA	21.3 Å²
Synonyms	Nordoxepin Hydrochloride (E/Z Mixture), N-Desmethyldoxepin hydrochloride, 1-Propanamine, 3-dibenz(b,e)oxepin-11(6H)-ylidene-N-methyl-, hydrochloride, Desmethyldoxepin hydrochloride, Desmethyldoxepin hydrochloride, (Z)-, N-Desmethyl (Z)-Doxepin Hydrochloride, 1-Propanamine, 3-dibenz(b,E)oxepin-11(6H)-ylidene-N-methyl-, hydrochloride (1:1), (3Z)-, 1-Propanamine, 3-dibenz(b,E)oxepin-11(6H)-ylidene-N-methyl-, hydrochloride, (Z)-, Desmethyldoxepin (hydrochloride), N-Desmethyldoxepin HCl, N-Desmethyl(Z)-DoxepinHydrochloride

Safety & hazard information (GHS)

Harmful / irritant

Environmental hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H400Very toxic to aquatic life

Precautionary statements: P264, P270, P273, P301 + P317, P330, P391, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of NorDoxepin Hydrochloride?

The CAS Registry Number of NorDoxepin Hydrochloride is 2887-91-4. It is also known as Nordoxepin Hydrochloride (E/Z Mixture), N-Desmethyldoxepin hydrochloride, 1-Propanamine, 3-dibenz(b,e)oxepin-11(6H)-ylidene-N-methyl-, hydrochloride.

What is the molecular formula and molecular weight of NorDoxepin Hydrochloride?

NorDoxepin Hydrochloride has the molecular formula C18H20ClNO and a molecular weight of 301.8 g/mol.

What is NorDoxepin Hydrochloride used for?

NorDoxepin Hydrochloride is supplied as a characterised reference material related to Doxepin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of NorDoxepin Hydrochloride can I order?

We supply NorDoxepin Hydrochloride in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with NorDoxepin Hydrochloride?

Yes. Every lot of NorDoxepin Hydrochloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can NorDoxepin Hydrochloride be shipped internationally?

Yes. NorDoxepin Hydrochloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.