4,5-Dichlorothiophene-2-carboxylic Acid

About 4,5-Dichlorothiophene-2-carboxylic Acid

4,5-Dichlorothiophene-2-carboxylic Acid is an impurity of Rivaroxaban carrying the CAS registry number 31166-29-7. Its molecular formula is C5H2Cl2O2S and its molecular weight is 197.04 g/mol. It is also known as 4,5-dichloro-2-thiophenecarboxylic acid or 2-Thiophenecarboxylic acid, 4,5-dichloro-.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Danger” with 7 hazard statements. Review the Safety Data Sheet before use.

This Rivaroxaban impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer 4,5-Dichlorothiophene-2-carboxylic Acid in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Rivaroxaban

View every impurity, metabolite and intermediate we list for Rivaroxaban.

Rivaroxaban impurities

Specifications & identifiers

Chemical identifiers
Product name	4,5-Dichlorothiophene-2-carboxylic Acid
Catalogue No.	VQ-027845
CAS Number	31166-29-7
IUPAC name	4,5-dichlorothiophene-2-carboxylic acid
Molecular formula	C₅H₂Cl₂O₂S
Molecular weight	197.04 g/mol
Exact mass	195.9153
Grade	Reference Standard
HSN code	38229090
InChIKey	JDBAYLWBVQVMTD-UHFFFAOYSA-N
SMILES	C1=C(SC(=C1Cl)Cl)C(=O)O
PubChem CID	305687

Physical properties
Physical form	Solid
LogP (XLogP3)	3.1
H-bond donors / acceptors	1 / 3
TPSA	65.5 Å²

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P305 + P354 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4,5-Dichlorothiophene-2-carboxylic Acid?

The CAS Registry Number of 4,5-Dichlorothiophene-2-carboxylic Acid is 31166-29-7. It is also known as 4,5-dichloro-2-thiophenecarboxylic acid, 2-Thiophenecarboxylic acid, 4,5-dichloro-, 2,3-dichlorothiophen-5-carboxylic acid.

What is the molecular formula and molecular weight of 4,5-Dichlorothiophene-2-carboxylic Acid?

4,5-Dichlorothiophene-2-carboxylic Acid has the molecular formula C5H2Cl2O2S and a molecular weight of 197.04 g/mol. Its IUPAC name is 4,5-dichlorothiophene-2-carboxylic acid.

What is 4,5-Dichlorothiophene-2-carboxylic Acid used for?

4,5-Dichlorothiophene-2-carboxylic Acid is supplied as a characterised reference material related to Rivaroxaban. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4,5-Dichlorothiophene-2-carboxylic Acid can I order?

We supply 4,5-Dichlorothiophene-2-carboxylic Acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4,5-Dichlorothiophene-2-carboxylic Acid?

Yes. Every lot of 4,5-Dichlorothiophene-2-carboxylic Acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4,5-Dichlorothiophene-2-carboxylic Acid be shipped internationally?

Yes. 4,5-Dichlorothiophene-2-carboxylic Acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.