(-) Corey Lactone

About (-) Corey Lactone

(-) Corey Lactone is an impurity of Iloprost carrying the CAS registry number 32233-40-2. Formula C8H12O4, molecular weight 172.18 g/mol. The IUPAC name is (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one. Common synonyms include (-)-Corey Lactone Diol and (-)-Corey's lactone diol.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Danger” with 4 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Iloprost to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Iloprost

View every impurity, metabolite and intermediate we list for Iloprost.

Iloprost impurities

Specifications & identifiers

Chemical identifiers
Product name	(-) Corey Lactone
Catalogue No.	VQ-031166
CAS Number	32233-40-2
IUPAC name	(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one
Molecular formula	C₈H₁₂O₄
Molecular weight	172.18 g/mol
Exact mass	172.0736
Grade	Reference Standard
HSN code	38229090
InChIKey	VYTZWRCSPHQSFX-GBNDHIKLSA-N
SMILES	C1[C@H]([C@@H]([C@@H]2[C@H]1OC(=O)C2)CO)O
PubChem CID	2724453

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.2
H-bond donors / acceptors	2 / 4
TPSA	66.8 Å²
Synonyms	(-)-Corey Lactone Diol, (-)-Corey's lactone diol, (3aR,4S,5R,6aS)-hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one, (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one, (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta(b)furan-2-one, (3aR,4S,5R,6aS)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta(b)furan-2-one, (3aR,4S,5R,6aS)-5-Hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one, Corey lactone Diol, rel-Corey lactone diol, Corey lactone diol, (-)-, rel-(3aR,4S,5R,6aS)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one, (1S,6S,5R,7R)-7-hydroxy-6-(hydroxymethyl)-2-oxabicyclo[3.3.0]octan-3-one

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H318Causes serious eye damage
H332Harmful if inhaled

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P354 + P338, P317, P321, P330, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (-) Corey Lactone?

The CAS Registry Number of (-) Corey Lactone is 32233-40-2. It is also known as (-)-Corey Lactone Diol, (-)-Corey's lactone diol, (3aR,4S,5R,6aS)-hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one.

What is the molecular formula and molecular weight of (-) Corey Lactone?

(-) Corey Lactone has the molecular formula C8H12O4 and a molecular weight of 172.18 g/mol. Its IUPAC name is (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one.

What is (-) Corey Lactone used for?

(-) Corey Lactone is supplied as a characterised reference material related to Iloprost. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (-) Corey Lactone can I order?

We supply (-) Corey Lactone in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (-) Corey Lactone?

Yes. Every lot of (-) Corey Lactone is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (-) Corey Lactone be shipped internationally?

Yes. (-) Corey Lactone is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.