Ethyl2-Chloro-3-oxopropanoate

About Ethyl2-Chloro-3-oxopropanoate

Ethyl2-Chloro-3-oxopropanoate is an impurity of Fluorouracil carrying the CAS registry number 33142-21-1. Formula C5H7ClO3, molecular weight 150.56 g/mol. It is also known as Ethyl (chloroformyl)acetate or 2-Chloro-3-oxopropanoic acid ethyl ester.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

This Fluorouracil impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Ethyl2-Chloro-3-oxopropanoate is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Fluorouracil

View every impurity, metabolite and intermediate we list for Fluorouracil.

Fluorouracil impurities

Specifications & identifiers

Chemical identifiers
Product name	Ethyl2-Chloro-3-oxopropanoate
Catalogue No.	VQ-048421
CAS Number	33142-21-1
IUPAC name	ethyl 2-chloro-3-oxopropanoate
Molecular formula	C₅H₇ClO₃
Molecular weight	150.56 g/mol
Exact mass	150.0084
Grade	Reference Standard
HSN code	38229090
InChIKey	DWXKSCKBUSAOKS-UHFFFAOYSA-N
SMILES	CCOC(=O)C(C=O)Cl
PubChem CID	118030

Physical properties
Physical form	Solid
LogP (XLogP3)	0.8
H-bond donors / acceptors	0 / 3
TPSA	43.4 Å²
Synonyms	Ethyl (chloroformyl)acetate, 2-Chloro-3-oxopropanoic acid ethyl ester, Propanoic acid, 2-chloro-3-oxo-, ethyl ester, Propanoic acid, 2-c, ethyl formylchloroacetate, ethyl alpha-formylchloroacetate, ethyl 2-chloro-2 formylacetate, ethyl alpha-chloro-formylacetate, ethyl alpha-formyl-chloroacetate, ethyl chloro-alpha-formylacetate, ethyl 2-chloro-3-oxo-propionate

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Ethyl2-Chloro-3-oxopropanoate?

The CAS Registry Number of Ethyl2-Chloro-3-oxopropanoate is 33142-21-1. It is also known as Ethyl (chloroformyl)acetate, 2-Chloro-3-oxopropanoic acid ethyl ester, Propanoic acid, 2-chloro-3-oxo-, ethyl ester.

What is the molecular formula and molecular weight of Ethyl2-Chloro-3-oxopropanoate?

Ethyl2-Chloro-3-oxopropanoate has the molecular formula C5H7ClO3 and a molecular weight of 150.56 g/mol. Its IUPAC name is ethyl 2-chloro-3-oxopropanoate.

What is Ethyl2-Chloro-3-oxopropanoate used for?

Ethyl2-Chloro-3-oxopropanoate is supplied as a characterised reference material related to Fluorouracil. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Ethyl2-Chloro-3-oxopropanoate can I order?

We supply Ethyl2-Chloro-3-oxopropanoate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Ethyl2-Chloro-3-oxopropanoate?

Yes. Every lot of Ethyl2-Chloro-3-oxopropanoate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Ethyl2-Chloro-3-oxopropanoate be shipped internationally?

Yes. Ethyl2-Chloro-3-oxopropanoate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.