1-Demethylcolchicine

Name: 1-Demethylcolchicine
Brand: Vaqora Chemicals
SKU: VQ-044259

About 1-Demethylcolchicine

Listed under CAS 3464-68-4, 1-Demethylcolchicine is a metabolite or degradation product of Colchicine available from Vaqora Chemicals. With the molecular formula C21H23NO6, it has a molar mass of 385.4 g/mol. Systematically, it is named N-[(7S)-1-hydroxy-2,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Analytical teams use this compound to identify metabolites and degradants of Colchicine, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer 1-Demethylcolchicine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Colchicine

View every impurity, metabolite and intermediate we list for Colchicine.

Colchicine impurities

Specifications & identifiers

Chemical identifiers
Product name	1-Demethylcolchicine
Catalogue No.	VQ-044259
CAS Number	3464-68-4
IUPAC name	N-[(7S)-1-hydroxy-2,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Molecular formula	C₂₁H₂₃NO₆
Molecular weight	385.4 g/mol
Exact mass	385.1525
Grade	Reference Standard
HSN code	38229090
InChIKey	IGLDJTYPTSDFND-HNNXBMFYSA-N
SMILES	CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)O)OC)OC
PubChem CID	18702

Physical properties
Physical form	Solid
LogP (XLogP3)	0.7
H-bond donors / acceptors	2 / 6
TPSA	94.1 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1-Demethylcolchicine?

The CAS Registry Number of 1-Demethylcolchicine is 3464-68-4. It is also known as (s)-N-(1-hydroxy-2,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide.

What is the molecular formula and molecular weight of 1-Demethylcolchicine?

1-Demethylcolchicine has the molecular formula C21H23NO6 and a molecular weight of 385.4 g/mol. Its IUPAC name is N-[(7S)-1-hydroxy-2,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide.

What is 1-Demethylcolchicine used for?

1-Demethylcolchicine is supplied as a characterised reference material related to Colchicine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1-Demethylcolchicine can I order?

We supply 1-Demethylcolchicine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1-Demethylcolchicine?

Yes. Every lot of 1-Demethylcolchicine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1-Demethylcolchicine be shipped internationally?

Yes. We export 1-Demethylcolchicine worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.