Bromhexine

About Bromhexine

Bromhexine is a high-purity reference standard of Bromhexine carrying the CAS registry number 3572-43-8. Formula C14H20Br2N2, molecular weight 376.13 g/mol. Systematically, it is named 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline. Common synonyms include Bromexine and Ezolvin.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Laboratories use this Bromhexine standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer Bromhexine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Bromhexine

View every impurity, metabolite and intermediate we list for Bromhexine.

Bromhexine impurities

Specifications & identifiers

Chemical identifiers
Product name	Bromhexine
Catalogue No.	VQ-007358
CAS Number	3572-43-8
IUPAC name	2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline
Molecular formula	C₁₄H₂₀Br₂N₂
Molecular weight	376.13 g/mol
Exact mass	375.9973
Grade	Reference Standard
HSN code	38229090
InChIKey	OJGDCBLYJGHCIH-UHFFFAOYSA-N
SMILES	CN(CC1=C(C(=CC(=C1)Br)Br)N)C2CCCCC2
PubChem CID	2442

Physical properties
Physical form	Solid
LogP (XLogP3)	4.3
H-bond donors / acceptors	1 / 2
TPSA	29.3 Å²
Synonyms	N-(2-Amino-3,5-dibromobenzyl)-N-methylcyclohexylamine, 2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzenemethanamine, 2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine, Bromexine, Ezolvin, Benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-, 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline, 2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline, N-cyclohexyl-N-methyl-(2-amino-3,5-dibrombenzyl)amine, 3,5-dibromo-N(alpha)-cyclohexyl-N(alpha)-methyltoluene-alpha-2-diamine, bromhexin von ct, Dur Elix

Safety & hazard information (GHS)

Environmental hazard

Signal word: Warning

Hazard statements

H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P273, P391, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Bromhexine?

The CAS Registry Number of Bromhexine is 3572-43-8. It is also known as N-(2-Amino-3,5-dibromobenzyl)-N-methylcyclohexylamine, 2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzenemethanamine, 2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine.

What is the molecular formula and molecular weight of Bromhexine?

Bromhexine has the molecular formula C14H20Br2N2 and a molecular weight of 376.13 g/mol. Its IUPAC name is 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline.

What is Bromhexine used for?

Bromhexine is supplied as a characterised reference material related to Bromhexine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Bromhexine can I order?

We supply Bromhexine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Bromhexine?

Yes. Every lot of Bromhexine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Bromhexine be shipped internationally?

Yes. Bromhexine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.