Isomenthol

About Isomenthol

Isomenthol is a process intermediate or related compound of Menthol carrying the CAS registry number 3623-52-7. With the molecular formula C10H20O, it has a molar mass of 156.26 g/mol. The IUPAC name is (1R,2S,5S)-5-methyl-2-propan-2-ylcyclohexan-1-ol. Common synonyms include (A+-)-Isomenthol and Menthol, trans-1,3,cis-1,4-.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

It is a process intermediate or related compound in the synthesis of Menthol, useful for route development, impurity fate-and-purge studies and analytical method development. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development
Fine chemical synthesis

Industries

Related to Menthol

View every impurity, metabolite and intermediate we list for Menthol.

Menthol impurities

Specifications & identifiers

Chemical identifiers
Product name	Isomenthol
Catalogue No.	VQ-031786
CAS Number	3623-52-7
IUPAC name	(1R,2S,5S)-5-methyl-2-propan-2-ylcyclohexan-1-ol
Molecular formula	C₁₀H₂₀O
Molecular weight	156.26 g/mol
Exact mass	156.1514
InChIKey	NOOLISFMXDJSKH-LPEHRKFASA-N
SMILES	C[C@H]1CC[C@H]([C@@H](C1)O)C(C)C
PubChem CID	6432468

Physical properties
Physical form	Solid
LogP (XLogP3)	3
H-bond donors / acceptors	1 / 1
TPSA	20.2 Å²
Synonyms	Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5S)-rel-, (A+-)-Isomenthol, Menthol, trans-1,3,cis-1,4-, (1R,2S,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol, Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1.alpha.,2.beta.,5.beta.)-, (1R,2S,5S)-5-Methyl-2-(1-methylethyl)cyclohexanol, Isomentol, (1)-Isomenthol, ( not+/-)-Isomenthol

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation

Precautionary statements: P264, P280, P302 + P352, P321, P332 + P317, P362 + P364

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Isomenthol?

The CAS Registry Number of Isomenthol is 3623-52-7. It is also known as Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5S)-rel-, (A+-)-Isomenthol, Menthol, trans-1,3,cis-1,4-.

What is the molecular formula and molecular weight of Isomenthol?

Isomenthol has the molecular formula C10H20O and a molecular weight of 156.26 g/mol. Its IUPAC name is (1R,2S,5S)-5-methyl-2-propan-2-ylcyclohexan-1-ol.

What is Isomenthol used for?

Isomenthol is supplied as a characterised reference material related to Menthol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Isomenthol can I order?

We supply Isomenthol, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Isomenthol?

Yes. Every lot of Isomenthol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Isomenthol be shipped internationally?

Yes. Isomenthol is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.