(S)-Cotinine N-Oxide

About (S)-Cotinine N-Oxide

(S)-Cotinine N-Oxide is a metabolite or degradation product of Nicotine Hemisulfate carrying the CAS registry number 36508-80-2. The compound has the formula C10H12N2O2, corresponding to a molecular weight of 192.21 g/mol. Its systematic (IUPAC) name is (5S)-1-methyl-5-(1-oxidopyridin-1-ium-3-yl)pyrrolidin-2-one. Alternative names: cotinine N-oxide and Cotinine-N-oxide.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Analytical teams use this compound to identify metabolites and degradants of Nicotine Hemisulfate, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Nicotine Hemisulfate

View every impurity, metabolite and intermediate we list for Nicotine Hemisulfate.

Nicotine Hemisulfate impurities

Specifications & identifiers

Chemical identifiers
Product name	(S)-Cotinine N-Oxide
Catalogue No.	VQ-049227
CAS Number	36508-80-2
IUPAC name	(5S)-1-methyl-5-(1-oxidopyridin-1-ium-3-yl)pyrrolidin-2-one
Molecular formula	C₁₀H₁₂N₂O₂
Molecular weight	192.21 g/mol
Exact mass	192.0899
Grade	Reference Standard
HSN code	38229090
InChIKey	CIPULDKLIIVIER-VIFPVBQESA-N
SMILES	CN1[C@@H](CCC1=O)C2=C[N+](=CC=C2)[O-]
PubChem CID	9815514

Physical properties
Physical form	Solid
LogP (XLogP3)	-1.3
H-bond donors / acceptors	0 / 2
TPSA	45.8 Å²
Synonyms	cotinine N-oxide, Cotinine-N-oxide, 3-[(2S)-1-methyl-5-oxopyrrolidin-2-yl]pyridin-1-ium-1-olate, 3-((2S)-1-Methyl-5-oxopyrrolidin-2-yl)pyridin-1-ium-1-olate, Cotinine-1-N-oxide, 2-pyrrolidinone, 1-methyl-5-(1-oxido-3-pyridinyl)-, (5S)-, 2-pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, N-oxide, (S)-, (5s)-1-methyl-5-(1-oxido-3-pyridinyl)-2-pyrrolidinone, (S)-1-methyl-5-(1-oxido-3-pyridinyl)-2-Pyrrolidinone, (S)-1-methyl-5-(3-pyridinyl)-2-Pyrrolidinone N-oxide, (S)-3-(1-Methyl-5-oxopyrrolidin-2-yl)pyridine 1-oxide, cotinin-N-oxid

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (S)-Cotinine N-Oxide?

The CAS Registry Number of (S)-Cotinine N-Oxide is 36508-80-2. It is also known as cotinine N-oxide, Cotinine-N-oxide, 3-[(2S)-1-methyl-5-oxopyrrolidin-2-yl]pyridin-1-ium-1-olate.

What is the molecular formula and molecular weight of (S)-Cotinine N-Oxide?

(S)-Cotinine N-Oxide has the molecular formula C10H12N2O2 and a molecular weight of 192.21 g/mol. Its IUPAC name is (5S)-1-methyl-5-(1-oxidopyridin-1-ium-3-yl)pyrrolidin-2-one.

What is (S)-Cotinine N-Oxide used for?

(S)-Cotinine N-Oxide is supplied as a characterised reference material related to Nicotine Hemisulfate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (S)-Cotinine N-Oxide can I order?

We supply (S)-Cotinine N-Oxide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (S)-Cotinine N-Oxide?

Yes. Every lot of (S)-Cotinine N-Oxide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (S)-Cotinine N-Oxide be shipped internationally?

Yes. (S)-Cotinine N-Oxide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.