2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid 375369-29-2

Name: 2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid
Brand: Vaqora Chemicals
SKU: VQ-044293

About 2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid

2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid (CAS 375369-29-2) is a metabolite or degradation product of Sitagliptin offered by Vaqora Chemicals. Formula C8H5F3O3, molecular weight 206.12 g/mol. Alternative names: 2,4,5-Trifluoromandelic acid.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Analytical teams use this compound to identify metabolites and degradants of Sitagliptin, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Sitagliptin

View every impurity, metabolite and intermediate we list for Sitagliptin.

Sitagliptin impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid
Catalogue No.	VQ-044293
CAS Number	375369-29-2
IUPAC name	2-hydroxy-2-(2,4,5-trifluorophenyl)acetic acid
Molecular formula	C₈H₅F₃O₃
Molecular weight	206.12 g/mol
Exact mass	206.0191
Grade	Reference Standard
HSN code	38229090
InChIKey	KGSNZRPLTBOIQG-UHFFFAOYSA-N
SMILES	C1=C(C(=CC(=C1F)F)F)C(C(=O)O)O
PubChem CID	44139266

Physical properties
Physical form	Solid
LogP (XLogP3)	1.1
H-bond donors / acceptors	2 / 6
TPSA	57.5 Å²

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid?

The CAS Registry Number of 2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid is 375369-29-2. It is also known as 2,4,5-Trifluoromandelic acid.

What is the molecular formula and molecular weight of 2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid?

2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid has the molecular formula C8H5F3O3 and a molecular weight of 206.12 g/mol. Its IUPAC name is 2-hydroxy-2-(2,4,5-trifluorophenyl)acetic acid.

What is 2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid used for?

2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid is supplied as a characterised reference material related to Sitagliptin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid can I order?

We supply 2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid?

Yes. Every lot of 2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid be shipped internationally?

Yes. 2-Hydroxy-2-(2,4,5-trifluorophenyl)acetic acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.