Tenofovir Alafenamide

Name: Tenofovir Alafenamide
Brand: Vaqora Chemicals
SKU: VQ-028256

About Tenofovir Alafenamide

Vaqora Chemicals supplies Tenofovir Alafenamide, an impurity of Tenofovir registered under CAS number 379270-37-8. Its molecular formula is C21H29N6O5P and its molecular weight is 476.5 g/mol. Systematically, it is named propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate. Alternative names: Tenofovir Alafenamide (SSR Isomer) and TFV Alafenamide.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Danger” with 5 hazard statements. Review the Safety Data Sheet before use.

This Tenofovir impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Tenofovir

View every impurity, metabolite and intermediate we list for Tenofovir.

Tenofovir impurities

Specifications & identifiers

Chemical identifiers
Product name	Tenofovir Alafenamide
Catalogue No.	VQ-028256
CAS Number	379270-37-8
IUPAC name	propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate
Molecular formula	C₂₁H₂₉N₆O₅P
Molecular weight	476.5 g/mol
Exact mass	476.1937
Grade	Reference Standard
HSN code	38229090
InChIKey	LDEKQSIMHVQZJK-CAQYMETFSA-N
SMILES	C[C@H](CN1C=NC2=C(N=CN=C21)N)OC[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC3=CC=CC=C3
PubChem CID	9574768

Physical properties
Physical form	Solid
LogP (XLogP3)	1.9
H-bond donors / acceptors	2 / 10
TPSA	143 Å²
Synonyms	Tenofovir Alafenamide (SSR Isomer), TFV Alafenamide, Tenofovir alafenamida, GS-7340 Tenofovir alafenamide, EX-A610, Tenofovir alafenamide (free base), US12049474, Compound TAF, Tenofovir Alafenamide (Prodrug of tenofovir), Sp-Tenofovir-phosphonamidate, phenyl, L-alanine isopropyl ester

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P305 + P354 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Tenofovir Alafenamide?

The CAS Registry Number of Tenofovir Alafenamide is 379270-37-8. It is also known as Tenofovir Alafenamide (SSR Isomer), TFV Alafenamide, Tenofovir alafenamida.

What is the molecular formula and molecular weight of Tenofovir Alafenamide?

Tenofovir Alafenamide has the molecular formula C21H29N6O5P and a molecular weight of 476.5 g/mol. Its IUPAC name is propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate.

What is Tenofovir Alafenamide used for?

Tenofovir Alafenamide is supplied as a characterised reference material related to Tenofovir. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Tenofovir Alafenamide can I order?

We supply Tenofovir Alafenamide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Tenofovir Alafenamide?

Yes. Every lot of Tenofovir Alafenamide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Tenofovir Alafenamide be shipped internationally?

Yes. Tenofovir Alafenamide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.