Diphenhydramine N-Oxide

Name: Diphenhydramine N-Oxide
Brand: Vaqora Chemicals
SKU: VQ-025338

About Diphenhydramine N-Oxide

Vaqora Chemicals supplies Diphenhydramine N-Oxide, a metabolite or degradation product of Diphenhydramine registered under CAS number 3922-74-5. Its molecular formula is C17H21NO2 and its molecular weight is 271.35 g/mol. Its systematic (IUPAC) name is 2-benzhydryloxy-N,N-dimethylethanamine oxide. Alternative names: Amoxydramine and (Dimethylamino)ethyl benzhydryl ether N-oxide.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Diphenhydramine, as well as in QC testing and ANDA/DMF documentation. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Diphenhydramine N-Oxide is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Diphenhydramine

View every impurity, metabolite and intermediate we list for Diphenhydramine.

Diphenhydramine impurities

Specifications & identifiers

Chemical identifiers
Product name	Diphenhydramine N-Oxide
Catalogue No.	VQ-025338
CAS Number	3922-74-5
IUPAC name	2-benzhydryloxy-N,N-dimethylethanamine oxide
Molecular formula	C₁₇H₂₁NO₂
Molecular weight	271.35 g/mol
Exact mass	271.1572
Grade	Reference Standard
HSN code	38229090
InChIKey	OEQNVWKWQPTBSC-UHFFFAOYSA-N
SMILES	C[N+](C)(CCOC(C1=CC=CC=C1)C2=CC=CC=C2)[O-]
PubChem CID	65618

Physical properties
Physical form	Solid
LogP (XLogP3)	2.7
H-bond donors / acceptors	0 / 2
TPSA	27.3 Å²
Synonyms	Amoxydramine, (Dimethylamino)ethyl benzhydryl ether N-oxide, Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, N-oxide, Ethylamine, 2-(diphenylmethoxy)-N,N-dimethyl-, N-oxide, Diphenhydramine N-xide, 2-benzhydryloxyethyl-dimethyl-oxido-azanium, 2-(Benzhydryloxy)-N,N-dimethylethan-1-amine oxide, 2-(Diphenylmethoxy)-N,N-dimethylethan-1-amine N-oxide

Safety & hazard information (GHS)

Toxic

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P264, P270, P280, P301 + P316, P318, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Diphenhydramine N-Oxide?

The CAS Registry Number of Diphenhydramine N-Oxide is 3922-74-5. It is also known as Amoxydramine, (Dimethylamino)ethyl benzhydryl ether N-oxide, Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, N-oxide.

What is the molecular formula and molecular weight of Diphenhydramine N-Oxide?

Diphenhydramine N-Oxide has the molecular formula C17H21NO2 and a molecular weight of 271.35 g/mol. Its IUPAC name is 2-benzhydryloxy-N,N-dimethylethanamine oxide.

What is Diphenhydramine N-Oxide used for?

Diphenhydramine N-Oxide is supplied as a characterised reference material related to Diphenhydramine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Diphenhydramine N-Oxide can I order?

We supply Diphenhydramine N-Oxide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Diphenhydramine N-Oxide?

Yes. Every lot of Diphenhydramine N-Oxide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Diphenhydramine N-Oxide be shipped internationally?

Yes. Diphenhydramine N-Oxide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.