4-Nitro-α-toluenesulfonyl chloride

Name: 4-Nitro-α-toluenesulfonyl chloride
Brand: Vaqora Chemicals
SKU: VQ-033990

About 4-Nitro-α-toluenesulfonyl chloride

Listed under CAS 4025-75-6, 4-Nitro-α-toluenesulfonyl chloride is an impurity of Sumatriptan available from Vaqora Chemicals. Formula C7H6ClNO4S, molecular weight 235.65 g/mol. The IUPAC name is (4-nitrophenyl)methanesulfonyl chloride. It is also known as (4-nitrophenyl)methanesulfonylchloride or 4-Nitrobenzylsulfonyl chloride.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Sumatriptan to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Sumatriptan

View every impurity, metabolite and intermediate we list for Sumatriptan.

Sumatriptan impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Nitro-α-toluenesulfonyl chloride
Catalogue No.	VQ-033990
CAS Number	4025-75-6
IUPAC name	(4-nitrophenyl)methanesulfonyl chloride
Molecular formula	C₇H₆ClNO₄S
Molecular weight	235.65 g/mol
Exact mass	234.9706
Grade	Reference Standard
HSN code	38229090
InChIKey	CAXRPEAFHWDFTD-UHFFFAOYSA-N
SMILES	C1=CC(=CC=C1CS(=O)(=O)Cl)[N+](=O)[O-]
PubChem CID	2794642

Physical properties
Physical form	Solid
LogP (XLogP3)	2.1
H-bond donors / acceptors	0 / 4
TPSA	88.3 Å²
Synonyms	(4-nitrophenyl)methanesulfonylchloride, 4-Nitrobenzylsulfonyl chloride, 4-nitrobenzyl sulfonyl chloride, 4-nitrobenzyl sulphonyl chloride, 4-nitrophenylmethanesulfonylchloride, 4-Nitro-, A-toluenesulfonyl chloride, 4-nitrophenylmethanesulfonyl chloride, chloro[(4-nitrophenyl)methyl]sulfone, 4-nitrophenylmethanesulphonyl chloride, (4-nitrophenyl)methanesulfonyl chloride, AldrichCPR

Safety & hazard information (GHS)

Flammable

Corrosive

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H261In contact with water releases flammable gas
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
H318Causes serious eye damage

Precautionary statements: P203, P231 + P232, P260, P261, P264, P264 + P265, P272, P280, P301 + P330 + P331, P302 + P352, P302 + P361 + P354, P304 + P340, P305 + P354 + P338, P316, P317, P318, P321, P333 + P317, P362 + P364, P363, P370 + P378, P402 + P404, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Nitro-α-toluenesulfonyl chloride?

The CAS Registry Number of 4-Nitro-α-toluenesulfonyl chloride is 4025-75-6. It is also known as (4-nitrophenyl)methanesulfonylchloride, 4-Nitrobenzylsulfonyl chloride, 4-nitrobenzyl sulfonyl chloride.

What is the molecular formula and molecular weight of 4-Nitro-α-toluenesulfonyl chloride?

4-Nitro-α-toluenesulfonyl chloride has the molecular formula C7H6ClNO4S and a molecular weight of 235.65 g/mol. Its IUPAC name is (4-nitrophenyl)methanesulfonyl chloride.

What is 4-Nitro-α-toluenesulfonyl chloride used for?

4-Nitro-α-toluenesulfonyl chloride is supplied as a characterised reference material related to Sumatriptan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Nitro-α-toluenesulfonyl chloride can I order?

We supply 4-Nitro-α-toluenesulfonyl chloride in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Nitro-α-toluenesulfonyl chloride?

Yes. Every lot of 4-Nitro-α-toluenesulfonyl chloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Nitro-α-toluenesulfonyl chloride be shipped internationally?

Yes. 4-Nitro-α-toluenesulfonyl chloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.