2-Hydroxy-3-methylbutyric Acid

About 2-Hydroxy-3-methylbutyric Acid

2-Hydroxy-3-methylbutyric Acid is a metabolite or degradation product of Butyric acid carrying the CAS registry number 4026-18-0. With the molecular formula C5H10O3, it has a molar mass of 118.13 g/mol. Systematically, it is named 2-hydroxy-3-methylbutanoic acid. Alternative names: 2-Hydroxyisovaleric acid and Butanoic acid, 2-hydroxy-3-methyl-.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Analytical teams use this compound to identify metabolites and degradants of Butyric acid, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 2-Hydroxy-3-methylbutyric Acid is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling
Fine chemical synthesis

Industries

Related to Butyric acid

View every impurity, metabolite and intermediate we list for Butyric acid.

Butyric acid impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Hydroxy-3-methylbutyric Acid
Catalogue No.	VQ-038989
CAS Number	4026-18-0
IUPAC name	2-hydroxy-3-methylbutanoic acid
Molecular formula	C₅H₁₀O₃
Molecular weight	118.13 g/mol
Exact mass	118.063
Grade	Reference Standard
HSN code	38229090
InChIKey	NGEWQZIDQIYUNV-UHFFFAOYSA-N
SMILES	CC(C)C(C(=O)O)O
PubChem CID	99823

Physical properties
Physical form	Solid
LogP (XLogP3)	0.5
H-bond donors / acceptors	2 / 3
TPSA	57.5 Å²
Synonyms	2-Hydroxyisovaleric acid, Butanoic acid, 2-hydroxy-3-methyl-, 3-Methyl-2-hydroxybutyric acid, alpha-hydroxyisovaleric acid, D-Valic acid, 2-Oxyisovaleric acid, DL-2-Hydroxyisovaleric acid, DL-2-Hydroxy-3-methylbutanoic acid, 2-Hydroxyisopentanoic acid, (1)-2-Hydroxy-3-methylbutyric acid, 2-Hydroxy-3-methylbutanoicacid, 2-Oxyisovalerate

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Hydroxy-3-methylbutyric Acid?

The CAS Registry Number of 2-Hydroxy-3-methylbutyric Acid is 4026-18-0. It is also known as 2-Hydroxyisovaleric acid, Butanoic acid, 2-hydroxy-3-methyl-, 3-Methyl-2-hydroxybutyric acid.

What is the molecular formula and molecular weight of 2-Hydroxy-3-methylbutyric Acid?

2-Hydroxy-3-methylbutyric Acid has the molecular formula C5H10O3 and a molecular weight of 118.13 g/mol. Its IUPAC name is 2-hydroxy-3-methylbutanoic acid.

What is 2-Hydroxy-3-methylbutyric Acid used for?

2-Hydroxy-3-methylbutyric Acid is supplied as a characterised reference material related to Butyric acid. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Hydroxy-3-methylbutyric Acid can I order?

We supply 2-Hydroxy-3-methylbutyric Acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Hydroxy-3-methylbutyric Acid?

Yes. Every lot of 2-Hydroxy-3-methylbutyric Acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Hydroxy-3-methylbutyric Acid be shipped internationally?

Yes. 2-Hydroxy-3-methylbutyric Acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.